PMID- 20851173
OWN - NLM
STAT- MEDLINE
DCOM- 20110429
LR  - 20211020
IS  - 1873-6815 (Electronic)
IS  - 0531-5565 (Print)
IS  - 0531-5565 (Linking)
VI  - 46
IP  - 2-3
DP  - 2011 Feb-Mar
TI  - Growth hormone, insulin and aging: the benefits of endocrine defects.
PG  - 108-11
LID - 10.1016/j.exger.2010.08.020 [doi]
AB  - Longevity of mice can be increased by spontaneous or experimentally induced 
      mutations that interfere with the biosynthesis or actions of growth hormone (GH), 
      insulin-like growth factor 1 (IGF-1), or insulin in the adipose tissue. The 
      effects of GH resistance and deficiency of GH (along with thyrotropin and 
      prolactin) on aging and lifespan are the most pronounced and best established of 
      these mutations. Potential mechanisms linking these endocrine deficits with 
      delayed aging and extended longevity include increased stress resistance, 
      alterations in insulin and mammalian target of rapamycin (mTOR) signaling and 
      metabolic adjustments. Physiological relationships deduced from the extreme 
      phenotypes of long-lived mouse mutants appear to apply broadly, encompassing 
      genetically normal ("wild-type") mice and other mammalian species. The role of GH 
      in the control of human aging continues to be hotly debated, but recent data 
      indicate that reduced somatotropic signaling provides protection from cancer and 
      other age-related diseases and may promote old age survival.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Bartke, Andrzej
AU  - Bartke A
AD  - Department of Internal Medicine, Southern Illinois University School of Medicine, 
      Springfield, IL 62794-9628, USA. abartke@siumed.edu
LA  - eng
GR  - P01 AG031736/AG/NIA NIH HHS/United States
GR  - R01 AG019899/AG/NIA NIH HHS/United States
GR  - R21 AG038850/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100917
PL  - England
TA  - Exp Gerontol
JT  - Experimental gerontology
JID - 0047061
RN  - 0 (Insulin)
RN  - 9002-72-6 (Growth Hormone)
SB  - IM
MH  - Animals
MH  - Endocrine System/*physiology
MH  - Growth Hormone/*physiology
MH  - Humans
MH  - Insulin/*physiology
MH  - Longevity/*physiology
MH  - Mice
PMC - PMC3408075
MID - NIHMS248254
EDAT- 2010/09/21 06:00
MHDA- 2011/04/30 06:00
PMCR- 2012/07/30
CRDT- 2010/09/21 06:00
PHST- 2010/05/14 00:00 [received]
PHST- 2010/08/23 00:00 [revised]
PHST- 2010/08/27 00:00 [accepted]
PHST- 2010/09/21 06:00 [entrez]
PHST- 2010/09/21 06:00 [pubmed]
PHST- 2011/04/30 06:00 [medline]
PHST- 2012/07/30 00:00 [pmc-release]
AID - S0531-5565(10)00264-0 [pii]
AID - 10.1016/j.exger.2010.08.020 [doi]
PST - ppublish
SO  - Exp Gerontol. 2011 Feb-Mar;46(2-3):108-11. doi: 10.1016/j.exger.2010.08.020. Epub 
      2010 Sep 17.