PMID- 20851633
OWN - NLM
STAT- MEDLINE
DCOM- 20120924
LR  - 20151119
IS  - 1532-8511 (Electronic)
IS  - 1052-3057 (Linking)
VI  - 21
IP  - 1
DP  - 2012 Jan
TI  - Proteomic biomarker discovery in cerebrospinal fluid for cerebral vasospasm 
      following subarachnoid hemorrhage.
PG  - 30-41
LID - 10.1016/j.jstrokecerebrovasdis.2010.04.004 [doi]
AB  - Currently, there are no established biomarkers for diagnosing preclinical 
      vasospasm or monitoring its progression. Two areas of extensive biomarker 
      research are neuroimaging and biochemical markers in body fluids, such as 
      cerebrospinal fluid (CSF). We performed a review of studies conducted over the 
      past 2 decades summarizing the science to date and the evolution of CSF 
      biomarkers in subarachnoid hemorrhage (SAH). A Medline search performed using the 
      search terms "subarachnoid hemorrhage marker AND cerebrospinal fluid," limited to 
      the period January 1, 1990 to June 1, 2009, returned 62 references. Abstracts 
      that did not deal primarily with SAH and potential markers in the CSF of humans 
      were excluded, resulting in 27 abstracts. Only articles providing sufficient 
      information for a substantiated analysis were selected. In addition, articles 
      identified in reference lists of individual articles were selected if considered 
      appropriate. Evidence was classified as class I-IV and recommendations were 
      classified as category A-C according to European Federation of Neurological 
      Societies guidelines. We evaluated CSF markers in SAH patients and divided them 
      into 3 categories: A, markers with auspicious value; B, candidate markers; and C, 
      noncandidate markers. Category A markers included tumor necrosis factor (TNF)-alpha, 
      soluble tumor necrosis factor receptor I (sTNFR-I), and interleukin (IL)-1 
      receptor antagonist (IL-1ra), as well as the neurofilament proteins NFL and NfH. 
      Category B markers included apolipoprotein E (ApoE), F2-isoprostane (F2-IsoP), 
      NOx, and the indicators for thrombin activity membrane-bound tissue factor (mTF) 
      and thrombin-antithrombin III complex (TAT) for neurologic outcome prediction, as 
      well as E-selectin, lactate, alpha-II spectrin breakdown products (SBDPs), 
      asymmetric dimethyl-L-arginine (ADMA), and monocyte chemoattractant protein-1 
      (MCP-1) for vasospasm prognostication. Category C markers included S100B, 
      platelet-derived growth factor (PDGF), YKL-40, chitotriosidase, intercellular 
      adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and 
      IL-8. Cytokines and their receptors, as well as neuronal intracellular proteins, 
      seem to be potential markers for outcome determination in patients after SAH.
CI  - (c) 2012 National Stroke Association.
FAU - Lad, Shivanand P
AU  - Lad SP
AD  - Department of Neurosurgery, Stanford University School of Medicine, Stanford, 
      California, USA. nlad@stanford.edu
FAU - Hegen, Harald
AU  - Hegen H
FAU - Gupta, Gaurav
AU  - Gupta G
FAU - Deisenhammer, Florian
AU  - Deisenhammer F
FAU - Steinberg, Gary K
AU  - Steinberg GK
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100919
PL  - United States
TA  - J Stroke Cerebrovasc Dis
JT  - Journal of stroke and cerebrovascular diseases : the official journal of National 
      Stroke Association
JID - 9111633
RN  - 0 (Biomarkers)
RN  - 0 (Nerve Tissue Proteins)
SB  - IM
MH  - Biomarkers/cerebrospinal fluid
MH  - Humans
MH  - Nerve Tissue Proteins/*cerebrospinal fluid/classification
MH  - Proteomics/*methods
MH  - Subarachnoid Hemorrhage/*cerebrospinal fluid/complications/*physiopathology
MH  - Vasospasm, Intracranial/*cerebrospinal fluid/*diagnosis/etiology
EDAT- 2010/09/21 06:00
MHDA- 2012/09/25 06:00
CRDT- 2010/09/21 06:00
PHST- 2010/02/21 00:00 [received]
PHST- 2010/04/09 00:00 [accepted]
PHST- 2010/09/21 06:00 [entrez]
PHST- 2010/09/21 06:00 [pubmed]
PHST- 2012/09/25 06:00 [medline]
AID - S1052-3057(10)00104-7 [pii]
AID - 10.1016/j.jstrokecerebrovasdis.2010.04.004 [doi]
PST - ppublish
SO  - J Stroke Cerebrovasc Dis. 2012 Jan;21(1):30-41. doi: 
      10.1016/j.jstrokecerebrovasdis.2010.04.004. Epub 2010 Sep 19.