PMID- 20851702
OWN - NLM
STAT- MEDLINE
DCOM- 20110805
LR  - 20220309
IS  - 1095-6867 (Electronic)
IS  - 0018-506X (Print)
IS  - 0018-506X (Linking)
VI  - 59
IP  - 3
DP  - 2011 Mar
TI  - Individual differences in the effect of social defeat on anhedonia and histone 
      acetylation in the rat hippocampus.
PG  - 331-7
LID - 10.1016/j.yhbeh.2010.09.005 [doi]
AB  - Major depression is a growing problem worldwide with variation in symptoms and 
      response to treatment. Individual differences in response to stress may 
      contribute to such observed individual variation in behavior and pathology. 
      Therefore, we investigated depressive-like behavior following exposure to 
      repeated social defeat in a rat model of individual differences in response to 
      novelty. Rats are known to exhibit either high locomotor activity and sustained 
      exploration (high responders, HR) or low activity with minimal exploration (low 
      responders, LR) in a novel environment. We measured anhedonia using the sucrose 
      preference test in HR and LR rats following exposure to social defeat stress or 
      in basal, non-defeated conditions. We then compared histone acetylation in the 
      hippocampus in HR and LR defeat and non-defeated rats and measured mRNA levels of 
      histone deacetylases (HDAC) 3, 4, 5, and Creb binding protein (CBP). We found 
      that basally, HR rats consumed more sucrose solution than LR rats, but reduced 
      consumption after exposure to defeat. LR rats' preference was unaffected by 
      social defeat. We found that HR rats had higher levels of histone acetylation on 
      H3K14 and H2B than LR rats in non-stress conditions. Following defeat, this 
      acetylation pattern changed differentially, with HR rats decreasing acetylation 
      of H3K14 and H2B and LR's increasing acetylation of H3K14. Acetylation on histone 
      H4 decreased following defeat with no individual variation. Basal differences in 
      CBP expression levels may underlie the observed acetylation pattern; however we 
      found no significant effects of defeat in levels of HDACs 3, 4, 5 in the 
      hippocampus.
CI  - Published by Elsevier Inc.
FAU - Hollis, F
AU  - Hollis F
AD  - Department of Biomedical Sciences, Florida State University College of Medicine, 
      Tallahassee, FL 32306, USA.
FAU - Duclot, F
AU  - Duclot F
FAU - Gunjan, A
AU  - Gunjan A
FAU - Kabbaj, M
AU  - Kabbaj M
LA  - eng
GR  - R21 MH081046-0182/MH/NIMH NIH HHS/United States
GR  - R01 MH087583-01A1/MH/NIMH NIH HHS/United States
GR  - R21 MH081046-01A2/MH/NIMH NIH HHS/United States
GR  - R21 MH083128/MH/NIMH NIH HHS/United States
GR  - R21 MH083128-01A2/MH/NIMH NIH HHS/United States
GR  - R01 MH087583/MH/NIMH NIH HHS/United States
GR  - R21 MH081046/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20100921
PL  - United States
TA  - Horm Behav
JT  - Hormones and behavior
JID - 0217764
RN  - 0 (Histones)
SB  - IM
MH  - Acetylation
MH  - Analysis of Variance
MH  - Animals
MH  - Behavior, Animal/physiology
MH  - *Dominance-Subordination
MH  - Exploratory Behavior/physiology
MH  - Hippocampus/*metabolism
MH  - Histones/*genetics/metabolism
MH  - *Individuality
MH  - Male
MH  - Motor Activity/genetics
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Stress, Psychological/*genetics/metabolism
PMC - PMC3037445
MID - NIHMS242183
EDAT- 2010/09/21 06:00
MHDA- 2011/08/06 06:00
PMCR- 2012/03/01
CRDT- 2010/09/21 06:00
PHST- 2010/03/25 00:00 [received]
PHST- 2010/08/12 00:00 [revised]
PHST- 2010/09/08 00:00 [accepted]
PHST- 2010/09/21 06:00 [entrez]
PHST- 2010/09/21 06:00 [pubmed]
PHST- 2011/08/06 06:00 [medline]
PHST- 2012/03/01 00:00 [pmc-release]
AID - S0018-506X(10)00246-1 [pii]
AID - 10.1016/j.yhbeh.2010.09.005 [doi]
PST - ppublish
SO  - Horm Behav. 2011 Mar;59(3):331-7. doi: 10.1016/j.yhbeh.2010.09.005. Epub 2010 Sep 
      21.