PMID- 20851819
OWN - NLM
STAT- MEDLINE
DCOM- 20110314
LR  - 20110608
IS  - 1879-0844 (Electronic)
IS  - 1388-9842 (Linking)
VI  - 12
IP  - 11
DP  - 2010 Nov
TI  - Insulin-like growth factor axis (insulin-like growth factor-I/insulin-like growth 
      factor-binding protein-3) as a prognostic predictor of heart failure: association 
      with adiponectin.
PG  - 1214-22
LID - 10.1093/eurjhf/hfq166 [doi]
AB  - AIMS: Insulin-like growth factor (IGF)-I is a regulator of glucose/fatty acid 
      metabolism and may be involved in the pathophysiology of cardiovascular disease, 
      but it remains unclear whether endogenous IGF-I is associated with the prognosis 
      of heart failure (HF). We investigated whether the IGF axis, the ratio of IGF-I 
      to IGF-binding protein-3 (IGFBP-3), was a predictor of clinical outcomes in HF. 
      The association of IGF axis with serum adiponectin level, a prognostic marker of 
      HF as well as a regulator of glucose/fatty acid metabolism, was also analysed. 
      METHODS AND RESULTS: We measured serum IGF-I and IGFBP-3 in 142 HF patients with 
      left ventricular systolic dysfunction and 63 control subjects. Patients with HF 
      underwent clinical assessment and measurement of adiponectin and B-type 
      natriuretic peptide (BNP). Compared with controls, HF patients showed 
      significantly decreased serum IGF axis values [median (inter-quartile ranges), 
      0.114 (0.063-0.150) vs. 0.099 (0.052-0.158), P = 0.042]. In HF patients, the 
      log-transformed IGF axis values were inversely correlated with the 
      log-transformed serum adiponectin levels (r = -0.35, P < 0.0001) and plasma BNP 
      levels (r = -0.25, P = 0.0028). The IGF axis was lower in patients with New York 
      Heart Association (NYHA) functional class III/IV than those with class I/II 
      [0.071 (0.044-0.145) vs. 0.107 (0.068-0.161), P = 0.022]. Furthermore, a decrease 
      in IGF axis was associated with increased rates of all-cause mortality (P = 
      0.013), cardiac death (P = 0.035), and a composite of cardiac death and 
      re-hospitalization (P = 0.0085). CONCLUSION: Insulin-like growth factor axis is a 
      significant predictor of clinical outcomes in HF and is significantly associated 
      with serum adiponectin levels.
FAU - Watanabe, Shin
AU  - Watanabe S
AD  - Department of Cardiovascular Medicine, Kyoto University Graduate School of 
      Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, Japan.
FAU - Tamura, Toshihiro
AU  - Tamura T
FAU - Ono, Koh
AU  - Ono K
FAU - Horiuchi, Hisanori
AU  - Horiuchi H
FAU - Kimura, Takeshi
AU  - Kimura T
FAU - Kita, Toru
AU  - Kita T
FAU - Furukawa, Yutaka
AU  - Furukawa Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100917
PL  - England
TA  - Eur J Heart Fail
JT  - European journal of heart failure
JID - 100887595
RN  - 0 (Adiponectin)
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
CIN - Eur J Heart Fail. 2010 Nov;12(11):1154-5. PMID: 20923855
MH  - Adiponectin/*physiology
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Heart Failure/*blood/*mortality/physiopathology
MH  - Humans
MH  - Insulin-Like Growth Factor Binding Protein 3/analysis/*physiology
MH  - Insulin-Like Growth Factor I/analysis/*physiology
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Natriuretic Peptide, Brain/blood
MH  - Prognosis
MH  - Proportional Hazards Models
EDAT- 2010/09/21 06:00
MHDA- 2011/03/15 06:00
CRDT- 2010/09/21 06:00
PHST- 2010/09/21 06:00 [entrez]
PHST- 2010/09/21 06:00 [pubmed]
PHST- 2011/03/15 06:00 [medline]
AID - hfq166 [pii]
AID - 10.1093/eurjhf/hfq166 [doi]
PST - ppublish
SO  - Eur J Heart Fail. 2010 Nov;12(11):1214-22. doi: 10.1093/eurjhf/hfq166. Epub 2010 
      Sep 17.