PMID- 20854093
OWN - NLM
STAT- MEDLINE
DCOM- 20110202
LR  - 20211203
IS  - 1557-8518 (Electronic)
IS  - 1540-4196 (Linking)
VI  - 8
IP  - 5
DP  - 2010 Oct
TI  - One-hour postload plasma glucose levels, a predictor of additional risk for 
      diabetes: prevalence, mechanisms, and associated cardiovascular and metabolic 
      risk factors in Hispanics.
PG  - 395-402
LID - 10.1089/met.2010.0010 [doi]
AB  - OBJECTIVE: The aim of this study was to determine the prevalence of and the 
      mechanisms by which elevated glucose concentrations at 1-h after a glucose load, 
      conferred increased risk for type 2 diabetes mellitus (T2DM). The study was 
      conducted in subjects with glucose abnormalities (impaired fasting glucose [IFG], 
      and impaired glucose tolerance [IGT]), as well as in normal fasting-normal 
      tolerant subjects (NFG-NGT). METHOD: One-hour plasma glucose concentrations were 
      measured as part of 0- to 180-min oral glucose tolerance test (OGTT) performed in 
      an unselected sample of 490 Latino-Hispanics. A cutoff of 154 mg/dL at 1-h during 
      the OGTT was employed, because higher glucose levels define subjects at increased 
      risk for T2DM. Surrogate markers of insulin sensitivity and release, and glucose 
      and insulin time courses were measured. Obesity, cardiovascular risk factors, and 
      presence of metabolic syndrome were also assessed. RESULTS: One-hour plasma 
      glucose concentrations above the cutoff (>/= 155 mg/dL) were found in 8.3% of 
      NFG-NGT, 43% of IFG, 65% of IGT, and in 90% of IFG + IGT, and were associated 
      with greater postload hyperglycemia (AUCG) and hyperinsulinemia (AUCI), and with 
      reductions in indices of beta-cell function (Delta I 0-30/Delta G 0-30 and Delta 
      I 0-180/Delta G 0-180), insulin sensitivity [Matsuda index, homeostasis model 
      assessment of insulin resistance (HOMA-IR)], and disposition index (Delta 
      0-30/Delta 0-30 G / HOMA-I), markers of increased risk of T2DM. In addition, 
      those with >/= 155 mg/dL were older, more obese, had higher blood pressure, and 
      higher prevalence of metabolic syndrome. These clinical and metabolic changes 
      were characteristic of subjects with 1-h plasma glucose concentrations >/= 155 
      mg/dL, irrespectively of whether they were classified as NFG-NGT, IFG, or IGT. 
      CONCLUSIONS: One-hour postload plasma glucose levels >/= 155 mg/dL identified a 
      subgroup of subjects, which by current guidelines are classified as NFG-NGT, IFG, 
      or IGT, but that are at a higher risk that their average group risk. Recognition 
      and management of these subjects may reduce incidence of diabetes and 
      cardiovascular events.
FAU - Cubeddu, Luigi X
AU  - Cubeddu LX
AD  - Department of Pharmaceutical Sciences, Nova Southeastern University, Fort 
      Lauderdale, Florida 33328, USA. lcubeddu@nova.edu
FAU - Hoffmann, Irene S
AU  - Hoffmann IS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Metab Syndr Relat Disord
JT  - Metabolic syndrome and related disorders
JID - 101150318
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Area Under Curve
MH  - Blood Glucose/*metabolism
MH  - Cardiovascular Diseases/*blood/diagnosis/ethnology
MH  - Diabetes Mellitus, Type 2/*blood/diagnosis/ethnology
MH  - Female
MH  - Glucose Tolerance Test/*methods
MH  - Hispanic or Latino
MH  - Humans
MH  - Male
MH  - Metabolic Diseases/*blood/diagnosis/ethnology
MH  - Middle Aged
MH  - Prevalence
MH  - Risk
MH  - Risk Factors
MH  - Time Factors
EDAT- 2010/09/22 06:00
MHDA- 2011/02/03 06:00
CRDT- 2010/09/22 06:00
PHST- 2010/09/22 06:00 [entrez]
PHST- 2010/09/22 06:00 [pubmed]
PHST- 2011/02/03 06:00 [medline]
AID - 10.1089/met.2010.0010 [doi]
PST - ppublish
SO  - Metab Syndr Relat Disord. 2010 Oct;8(5):395-402. doi: 10.1089/met.2010.0010.