PMID- 2085462
OWN - NLM
STAT- MEDLINE
DCOM- 19910523
LR  - 20081121
IS  - 1044-9523 (Print)
IS  - 1044-9523 (Linking)
VI  - 1
IP  - 2
DP  - 1990 Feb
TI  - Differential expression of human leukocyte antigen-A, -B, and -C locus specific 
      genes in trophoblast and embryonic cells.
PG  - 73-8
AB  - Research on the escape mechanism of the fetoplacental unit has focused on the 
      placental trophoblast, which is though to play an important role in the survival 
      of the fetus. There are two major findings in the present study: (a) The 
      expression of human leukocyte antigen (HLA)-A, -B, and -C locus specific genes is 
      greatly reduced in trophoblast cells compared to embryonic cells by Northern blot 
      analysis using locus specific oligonucleotide probes. This is true even though 
      the transcripts detected by a complementary DNA probe, which contains a very 
      conserved sequence present in all members of the HLA gene family, are equally 
      abundant in trophoblast and embryonic cells. (b) When trophoblast cells or 
      embryonic cells are cocultured with peripheral blood lymphocytes from the 
      corresponding female in the presence of recombinant interleukin 2, allogeneic 
      cytotoxic T lymphocytes are generated only in cultures with embryonic cells, and 
      trophoblast cells express the resistance to lysis by the allogeneic cytotoxic T 
      lymphocytes. These results strongly suggest that the reduction in expression of 
      transplantation antigens (HLA-A, -B, and -C) might address the question why 
      maternal tissue does not reject trophoblast cells.
FAU - Yahata, G
AU  - Yahata G
AD  - Department of Obstetrics and Gynecology, Niigata University School of Medicine, 
      Japan.
FAU - Ueda, H
AU  - Ueda H
FAU - Takakuwa, K
AU  - Takakuwa K
FAU - Kodama, S
AU  - Kodama S
FAU - Tanaka, K
AU  - Tanaka K
FAU - Kanazawa, K
AU  - Kanazawa K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Cell Growth Differ
JT  - Cell growth & differentiation : the molecular biology journal of the American 
      Association for Cancer Research
JID - 9100024
RN  - 0 (DNA Probes)
RN  - 0 (HLA Antigens)
RN  - 0 (Interleukin-2)
RN  - 0 (RNA, Messenger)
RN  - 0 (Recombinant Proteins)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Base Sequence
MH  - Blotting, Northern
MH  - Cell Communication
MH  - Cells, Cultured
MH  - DNA/genetics
MH  - DNA Probes
MH  - Embryo, Mammalian/*immunology/metabolism
MH  - Female
MH  - *Gene Expression Regulation
MH  - *Genes, MHC Class I
MH  - HLA Antigens/biosynthesis/*genetics
MH  - Humans
MH  - Interleukin-2/pharmacology
MH  - Killer Cells, Natural/immunology
MH  - Lymphocytes/drug effects
MH  - Molecular Sequence Data
MH  - Pregnancy/*immunology
MH  - RNA, Messenger/biosynthesis
MH  - Recombinant Proteins/pharmacology
MH  - Sequence Homology, Nucleic Acid
MH  - T-Lymphocytes, Cytotoxic/immunology
MH  - Trophoblasts/*immunology/metabolism
EDAT- 1990/02/01 00:00
MHDA- 1990/02/01 00:01
CRDT- 1990/02/01 00:00
PHST- 1990/02/01 00:00 [pubmed]
PHST- 1990/02/01 00:01 [medline]
PHST- 1990/02/01 00:00 [entrez]
PST - ppublish
SO  - Cell Growth Differ. 1990 Feb;1(2):73-8.