PMID- 20854863
OWN - NLM
STAT- MEDLINE
DCOM- 20110316
LR  - 20221207
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 71
IP  - 12
DP  - 2010 Dec
TI  - Characterization of tumor necrosis factor-alpha block haplotypes associated with 
      susceptibility to chronic venous leg ulcers in Caucasian patients.
PG  - 1214-9
LID - 10.1016/j.humimm.2010.09.001 [doi]
AB  - Polymorphisms in the central major histocompatibility complex (MHC) are 
      associated with several immunopathologic and inflammatory diseases, including 
      chronic venous leg ulcers (CVLU). Because of strong linkage disequilibrium, 
      identification of loci affecting disease susceptibility must be based on 
      comparisons between haplotypes. Here we examine the association of conserved 
      tumor necrosis factor (TNF) block haplotypes with CVLU susceptibility. A total of 
      171 Caucasian patients with CVLU were compared with 173 age-/gender-matched 
      controls, excluding individuals with type 1 diabetes or rheumatoid arthritis. A 
      total of 194 healthy subjects formed a separate population-based control group. 
      Samples were typed for 38 tumor necrosis factor (TNF) block single nucleotide 
      polymorphisms (SNP), human leukocyte antigen (HLA)-B and HLA-DRB1 alleles. TNF 
      haplotypes were derived using the PHASE algorithm and assigned numbers (FVx) 
      defined previously. The patients and matched controls shared 16 TNF block 
      haplotypes. The patients had increased carriage of FV16 and alleles of the 8.1 
      and 60.3 MHC ancestral haplotypes (AH). CVLU risk is modulated by alleles within 
      FV16 (e.g., TNF-308A and BAT1intron10 C insertion) or near FV16 in the 8.1AH. 
      CVLU risk may also be mediated by unidentified alleles (not in FV22) marked by 
      HLA-B40 and HLA-DR13. FV16 appears to be the best MHC and TNF block marker of 
      susceptibility. After disease onset, an individual's TNF block haplotype does not 
      modulate CVLU severity.
CI  - Copyright (c) 2010 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Tan, Joo-Huang
AU  - Tan JH
AD  - School of Pathology and Laboratory Medicine, University of Western Australia, 
      Perth, Australia.
FAU - Price, Patricia
AU  - Price P
FAU - Gut, Ivo
AU  - Gut I
FAU - Stacey, Michael C
AU  - Stacey MC
FAU - Warrington, Nicole M
AU  - Warrington NM
FAU - Wallace, Hilary J
AU  - Wallace HJ
LA  - eng
PT  - Journal Article
DEP - 20100918
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Chronic Disease
MH  - *Disease Susceptibility
MH  - Female
MH  - Gene Frequency
MH  - Haplotypes/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - Tumor Necrosis Factor-alpha/*genetics
MH  - Varicose Ulcer/*genetics
MH  - White People/*genetics
EDAT- 2010/09/22 06:00
MHDA- 2011/03/17 06:00
CRDT- 2010/09/22 06:00
PHST- 2009/12/20 00:00 [received]
PHST- 2010/08/30 00:00 [revised]
PHST- 2010/08/09 00:00 [accepted]
PHST- 2010/09/22 06:00 [entrez]
PHST- 2010/09/22 06:00 [pubmed]
PHST- 2011/03/17 06:00 [medline]
AID - S0198-8859(10)00494-5 [pii]
AID - 10.1016/j.humimm.2010.09.001 [doi]
PST - ppublish
SO  - Hum Immunol. 2010 Dec;71(12):1214-9. doi: 10.1016/j.humimm.2010.09.001. Epub 2010 
      Sep 18.