PMID- 20855054
OWN - NLM
STAT- MEDLINE
DCOM- 20101217
LR  - 20220317
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 150
IP  - 6
DP  - 2010 Dec
TI  - Optical coherence tomographic characteristics of microaneurysms in diabetic 
      retinopathy.
PG  - 840-8
LID - 10.1016/j.ajo.2010.06.015 [doi]
AB  - PURPOSE: To characterize microaneurysms in diabetic retinopathy (DR) depicted by 
      spectral-domain optical coherence tomography (SD-OCT). DESIGN: Retrospective, 
      observational case series. METHODS: We surveyed a consecutive series of 76 eyes 
      from 60 patients with DR (22 mild nonproliferative diabetic retinopathy [NPDR]; 
      43 moderate NPDR; 9 severe NPDR; 2 proliferative diabetic retinopathy [PDR]) who 
      underwent Spectralis OCT, fluorescein angiography (FA), and color fundus 
      photography on the same day. The microaneurysms on OCT were oval and well 
      demarcated at the points where those on color fundus photographs and FA were 
      delineated. The characteristics of microaneurysms were evaluated. RESULTS: Based 
      on the status of the capsular structure shown in the sectional images of OCT 
      (called ring sign), we classified 147 microaneurysms depicted by all of SD-OCT, 
      FA, and color fundus photographs in 76 eyes: 28 with complete ring sign, 54 with 
      incomplete one, and 65 with no structure. Microaneurysms with no ring sign had 
      hyperreflective spots in the lumen and were accompanied by nearby cystoid spaces 
      more frequently than other types (P = .033 and P = .007). Thirteen of 75 
      microaneurysms with nearby cystoid spaces protruded into the cystoid spaces, and 
      11 of those 13 microaneurysms presented with no ring sign. Microaneurysms resided 
      mainly in the inner nuclear layer (INL) (80.3%), and 65 of such microaneurysms 
      (55.1%) were accompanied by nearby cystoid spaces. CONCLUSIONS: SD-OCT delineated 
      the capsular structure, hyperreflective spots, and location of microaneurysms, 
      and microaneurysms with the ring sign were positively correlated with nearby 
      cystoid spaces and protrusion into the cystoid spaces.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Horii, Takahiro
AU  - Horii T
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School 
      of Medicine, Kyoto, Japan.
FAU - Murakami, Tomoaki
AU  - Murakami T
FAU - Nishijima, Kazuaki
AU  - Nishijima K
FAU - Sakamoto, Atsushi
AU  - Sakamoto A
FAU - Ota, Masafumi
AU  - Ota M
FAU - Yoshimura, Nagahisa
AU  - Yoshimura N
LA  - eng
PT  - Journal Article
DEP - 20100919
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aneurysm/*diagnosis
MH  - Diabetic Retinopathy/classification/*diagnosis
MH  - Female
MH  - Fluorescein Angiography
MH  - Humans
MH  - Macular Edema/diagnosis
MH  - Male
MH  - Middle Aged
MH  - Retinal Vessels/*pathology
MH  - Retrospective Studies
MH  - *Tomography, Optical Coherence
EDAT- 2010/09/22 06:00
MHDA- 2010/12/18 06:00
CRDT- 2010/09/22 06:00
PHST- 2010/01/25 00:00 [received]
PHST- 2010/06/14 00:00 [revised]
PHST- 2010/06/15 00:00 [accepted]
PHST- 2010/09/22 06:00 [entrez]
PHST- 2010/09/22 06:00 [pubmed]
PHST- 2010/12/18 06:00 [medline]
AID - S0002-9394(10)00441-1 [pii]
AID - 10.1016/j.ajo.2010.06.015 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2010 Dec;150(6):840-8. doi: 10.1016/j.ajo.2010.06.015. Epub 2010 
      Sep 19.