PMID- 2085508
OWN - NLM
STAT- MEDLINE
DCOM- 19910520
LR  - 20191022
IS  - 0923-1811 (Print)
IS  - 0923-1811 (Linking)
VI  - 1
IP  - 3
DP  - 1990 May
TI  - Comparison of IgG subclass autoantibodies in patients with systemic lupus 
      erythematosus and subacute cutaneous lupus erythematosus.
PG  - 207-15
AB  - Circulating antinuclear antibodies and in vivo bound immunoglobulins at the 
      dermal-epidermal junction are frequently seen in patients with lupus 
      erythematosus. The present study was designed to examine the distribution of the 
      IgG subclasses of in vivo skin bound IgG and circulating antinuclear antibodies 
      (ANA) in patients with systemic lupus erythematosus (SLE) or subacute cutaneous 
      lupus erythematosus (SCLE). Immunofluorescence studies on skin biopsies showed 
      IgG1 to be the predominant IgG subclass in SCLE patients, present in 20 of 21 
      (95%) of the specimens. IgG2 was present in 4 patients (19%), IgG3 in 1 (5%), and 
      IgG4 in 7 (33%). The frequencies of IgG2, IgG3, and IgG4 skin staining were 
      significantly higher in the seven SLE patients who were studied: IgG1 in 7/7 
      (100%), IgG2 in 7/7 (100%) and IgG4 in 6/7 (86%). Immunoblot analysis for the IgG 
      subclasses was performed on serum of 29 patients with SCLE who had antibodies to 
      SSA/Ro antigen. Twenty-seven (93%) of these patients were positive for IgG1 
      anti-SSA/Ro antibody, while the frequencies for IgG2, IgG3, and IgG4 anti-SSA/Ro 
      were very low. These studies indicate that there is a difference in the IgG 
      subclass antibody response in patients with SLE and SCLE. The presence of more 
      than one subclass antibody may be indicative of systemic disease.
FAU - Elenitsas, R
AU  - Elenitsas R
AD  - Department of Dermatology, University of Pittsburgh School of Medicine, 
      Pennsylvania.
FAU - Abell, E
AU  - Abell E
FAU - Lee, Y Y
AU  - Lee YY
FAU - Huang, J
AU  - Huang J
FAU - Deng, J S
AU  - Deng JS
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Dermatol Sci
JT  - Journal of dermatological science
JID - 9011485
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Autoantibodies)
RN  - 0 (Immunoglobulin G)
RN  - 0 (SS-A antibodies)
SB  - IM
MH  - Antibodies, Antinuclear/immunology
MH  - Antibodies, Monoclonal/immunology
MH  - Antibody Specificity/immunology
MH  - Autoantibodies/*immunology
MH  - Fluorescent Antibody Technique
MH  - Humans
MH  - Immunoblotting
MH  - Immunoglobulin G/classification/*immunology
MH  - Lupus Erythematosus, Cutaneous/*immunology
MH  - Lupus Erythematosus, Systemic/*immunology
EDAT- 1990/05/01 00:00
MHDA- 1990/05/01 00:01
CRDT- 1990/05/01 00:00
PHST- 1990/05/01 00:00 [pubmed]
PHST- 1990/05/01 00:01 [medline]
PHST- 1990/05/01 00:00 [entrez]
AID - 0923-1811(90)90133-X [pii]
AID - 10.1016/0923-1811(90)90133-x [doi]
PST - ppublish
SO  - J Dermatol Sci. 1990 May;1(3):207-15. doi: 10.1016/0923-1811(90)90133-x.