PMID- 20855682
OWN - NLM
STAT- MEDLINE
DCOM- 20101012
LR  - 20220409
IS  - 1538-361X (Electronic)
IS  - 0886-4470 (Linking)
VI  - 136
IP  - 9
DP  - 2010 Sep
TI  - Plasma levels of MCP-1 and adiponectin in obstructive sleep apnea syndrome.
PG  - 896-9
LID - 10.1001/archoto.2010.142 [doi]
AB  - OBJECTIVES: To evaluate the correlation between concentrations of the 
      proinflammatory cytokines monocyte chemotactic protein 1 (MCP-1), adiponectin, 
      interleukin 6 (IL-6), interleukin 8 (IL-8), and tumor necrosis factor (TNF) and 
      patients with obstructive sleep apnea syndrome (OSAS). Repeated apnea attacks in 
      patients with OSAS constitute a hypoxic condition, which induces tissue 
      inflammation by mediation of these proinflammatory cytokines. DESIGN: 
      Radioimmunoassay analyses of nonrandomized controlled trial. SETTING: 
      University-affiliated tertiary care hospital. PATIENTS: The study population 
      comprised 59 patients who underwent the polysomnography. MAIN OUTCOME MEASURES: 
      Serum concentrations of MCP-1, adiponectin, IL-6, IL-8, and TNF, as well as body 
      mass index and polysomnographic data, including apnea-hypopnea index (AHI) and 
      lowest oxygen saturation. RESULTS: The mean (SD) plasma level of MCP-1 in serum 
      was increased in all patients with OSAS (P < .001), while adiponectin level was 
      decreased in the patients with severe OSAS (6.88 [1.78] mug/mL) compared with 
      normal controls (8.90 [2.63] mug/mL) (P = .006). Serum concentrations of IL-6, 
      IL-8, and TNF did not exhibit any differences between patients with OSAS and 
      normal controls. The correlation coefficient between plasma MCP-1 level and AHI 
      was 0.62 and between adiponectin level and AHI was 0.66. CONCLUSIONS: Our results 
      suggest that plasma MCP-1 and adiponectin levels were different between patients 
      with OSAS and normal controls. Adiponectin and MCP-1 may be prognostic factors 
      for comparing patients with OSAS before and after treatment.
FAU - Kim, Joohwan
AU  - Kim J
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, The 
      Catholic University of Korea, Yeongdeungpo-gu, Seoul 150-713, Korea.
FAU - Lee, Chang Hoon
AU  - Lee CH
FAU - Park, Chan Soon
AU  - Park CS
FAU - Kim, Byung Guk
AU  - Kim BG
FAU - Kim, Soo Whan
AU  - Kim SW
FAU - Cho, Jin Hee
AU  - Cho JH
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PL  - United States
TA  - Arch Otolaryngol Head Neck Surg
JT  - Archives of otolaryngology--head & neck surgery
JID - 8603209
RN  - 0 (Adiponectin)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukin-8)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adiponectin/*blood
MH  - Adult
MH  - Chemokine CCL2/*blood
MH  - Female
MH  - Humans
MH  - Interleukin-6/blood
MH  - Interleukin-8/blood
MH  - Male
MH  - Polysomnography
MH  - Radioimmunoassay
MH  - Sleep Apnea, Obstructive/*blood/physiopathology
MH  - Tumor Necrosis Factor-alpha/blood
EDAT- 2010/09/22 06:00
MHDA- 2010/10/13 06:00
CRDT- 2010/09/22 06:00
PHST- 2010/09/22 06:00 [entrez]
PHST- 2010/09/22 06:00 [pubmed]
PHST- 2010/10/13 06:00 [medline]
AID - 136/9/896 [pii]
AID - 10.1001/archoto.2010.142 [doi]
PST - ppublish
SO  - Arch Otolaryngol Head Neck Surg. 2010 Sep;136(9):896-9. doi: 
      10.1001/archoto.2010.142.