PMID- 20859200
OWN - NLM
STAT- MEDLINE
DCOM- 20110304
LR  - 20161125
IS  - 1473-5830 (Electronic)
IS  - 0954-6928 (Linking)
VI  - 21
IP  - 8
DP  - 2010 Dec
TI  - Relation between serum monocyte chemoattractant protein-1 and coronary collateral 
      development.
PG  - 455-9
LID - 10.1097/MCA.0b013e32833fd29b [doi]
AB  - BACKGROUND: The degree of coronary collateral development is not same in every 
      patient with similar degree of coronary stenosis. In animal studies monocyte 
      chemoattractant protein-1 (MCP-1) has been found to be related to collateral 
      vessel development. In this study we investigated whether a higher serum MCP-1 
      level is related to better coronary collateral vessel development in patients 
      with stable coronary artery disease. METHOD: Eighty-three patients with stable 
      angina pectoris, who have at least one coronary stenosis equal to or greater than 
      70% at coronary angiography, were prospectively enrolled. Serum MCP-1 and 
      vascular endothelial growth factor (VEGF) levels were studied. Coronary 
      collateral development was graded according to the Rentrop method. Patients with 
      grade 2-3 collateral developments were included in good collateral group and 
      formed group I. The patients with grade 0-1 collateral developments were included 
      in poor collateral group and formed group II. RESULTS: The serum MCP-1 level was 
      significantly higher in good collateral group (288 +/- 277 pg/ml vs. 132 +/- 64 
      pg/ml; P<0.001). There was also a positive correlation between serum MCP-1 level 
      and Rentrop score (r=0.39, P<0.001). The patients in the good collateral group 
      also had a significantly higher number of coronary arteries with significant 
      stenosis (1.7 +/- 0.7 vs. 1.4 +/- 0.6, P=0.049), and higher VEGF levels (322 +/- 147 
      pg/ml vs. 225 +/- 161 pg/ml, P=0.007). In multivariate analysis, only serum MCP-1 
      level (P=0.014, odds ratio: 1.01, 95% confidence interval: 1.002-1.019) was 
      independently related to good coronary collateral development. CONCLUSION: Higher 
      serum MCP-1 level is related to better coronary collateral development.
FAU - Sahinarslan, Asife
AU  - Sahinarslan A
AD  - Department of Cardiology, School of Medicine, Gazi University, Ankara, Turkey. 
      asifesah@yahoo.com
FAU - Kocaman, Sinan A
AU  - Kocaman SA
FAU - Topal, Salih
AU  - Topal S
FAU - Ercin, Ugur
AU  - Ercin U
FAU - Bukan, Neslihan
AU  - Bukan N
FAU - Yalcin, Ridvan
AU  - Yalcin R
FAU - Timurkaynak, Timur
AU  - Timurkaynak T
LA  - eng
PT  - Journal Article
PL  - England
TA  - Coron Artery Dis
JT  - Coronary artery disease
JID - 9011445
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (VEGFA protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Chemokine CCL2/*blood
MH  - *Collateral Circulation
MH  - Coronary Angiography
MH  - *Coronary Circulation
MH  - Coronary Stenosis/*blood/diagnostic imaging/*physiopathology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Severity of Illness Index
MH  - Turkey
MH  - Vascular Endothelial Growth Factor A/blood
EDAT- 2010/09/23 06:00
MHDA- 2011/03/05 06:00
CRDT- 2010/09/23 06:00
PHST- 2010/09/23 06:00 [entrez]
PHST- 2010/09/23 06:00 [pubmed]
PHST- 2011/03/05 06:00 [medline]
AID - 10.1097/MCA.0b013e32833fd29b [doi]
PST - ppublish
SO  - Coron Artery Dis. 2010 Dec;21(8):455-9. doi: 10.1097/MCA.0b013e32833fd29b.