PMID- 2086020
OWN - NLM
STAT- MEDLINE
DCOM- 19910523
LR  - 20140226
IS  - 0578-1426 (Print)
IS  - 0578-1426 (Linking)
VI  - 29
IP  - 8
DP  - 1990 Aug
TI  - [Changes in the levels of human platelet membrane glycoproteins in patients with 
      a new-type defect of platelet aggregation].
PG  - 489-90, 511-2
AB  - Labeled avidin-biotin (LAB)-enzyme linked immunosorbent assay (ELISA) for 
      quantitative measurement of the levels of human platelet membrane glycoproteins 
      (GPs) Ib, IIb and IIIa was developed by using a group of murine monoclonal 
      antibodies raised against human platelet membrane GPs. The contents of the GPs 
      Ib, IIb and IIIa in patients with a new-type defect of platelet aggregation were 
      detected and found to be in normal range. However, the amounts of GPs IIb and 
      IIIa before washing in patients were significantly decreased in these patients 
      when compared with those in controls (P less than 0.01), while after washing, 
      normal levels could be obtained. The results reported have support the hypothesis 
      that the pathogenesis of this defect in platelet aggregation seems not to be 
      associated with the abnormality of the levels of GPs, but is a result of abnormal 
      factor existing in the plasma. Further investigation on the properties of the 
      factor is in progress.
FAU - Liu, X Y
AU  - Liu XY
AD  - Union Hospital, Tongji Medical University.
FAU - Shen, D
AU  - Shen D
FAU - Wang, A L
AU  - Wang AL
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Nei Ke Za Zhi
JT  - Zhonghua nei ke za zhi
JID - 16210490R
RN  - 0 (Platelet Membrane Glycoproteins)
SB  - IM
MH  - Blood Platelet Disorders/*blood
MH  - Enzyme-Linked Immunosorbent Assay/methods
MH  - Humans
MH  - *Platelet Aggregation
MH  - Platelet Membrane Glycoproteins/*metabolism
EDAT- 1990/08/01 00:00
MHDA- 1990/08/01 00:01
CRDT- 1990/08/01 00:00
PHST- 1990/08/01 00:00 [pubmed]
PHST- 1990/08/01 00:01 [medline]
PHST- 1990/08/01 00:00 [entrez]
PST - ppublish
SO  - Zhonghua Nei Ke Za Zhi. 1990 Aug;29(8):489-90, 511-2.