PMID- 20860585
OWN - NLM
STAT- MEDLINE
DCOM- 20110526
LR  - 20101215
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 77
IP  - 1
DP  - 2011 Jan
TI  - Seventy-eight novel HLA class I and II alleles identified during routine registry 
      typing in 2008 and 2009.
PG  - 54-61
LID - 10.1111/j.1399-0039.2010.01558.x [doi]
AB  - Seventy-eight novel human leukocyte antigen (HLA) class I and class II alleles 
      are described: 19 HLA-A alleles, 30 HLA-C alleles, 21 HLA-B alleles, 7 HLA-DRB1 
      alleles and 1 HLA-DPB1 allele. Eight ( approximately 10%) of the novel alleles were found in 
      more than one individual and may be more common in the population. Sixty-two 
      ( approximately 80%) of the 78 novel alleles are single nucleotide substitution variants when 
      compared with their most homologous allele. Twelve of these single nucleotide 
      variants are silent substitutions and one creates a null allele (C*08:26N). One 
      of the novel HLA-C alleles, C*03:58, is a hybrid that likely resulted from an 
      intra-locus recombination. The remaining novel alleles differ from their most 
      similar allele by two to seven nucleotide substitutions. Four of the novel HLA-C 
      alleles encode amino acid changes at codons 41, 42, 55 or 200 which have not 
      previously been reported to be polymorphic. Some of the new alleles encode novel 
      codons and unique amino acid changes at polymorphic positions in the HLA-A 
      (codons 55 and 120), HLA-C (codons 151, 153 and 176), HLA-B (codons 31 and 84) 
      and HLA-DRB1 (codon 47) loci.
CI  - (c) 2010 John Wiley & Sons A/S.
FAU - Lazaro, A M
AU  - Lazaro AM
AD  - Department of Pediatrics, C.W. Bill Young Marrow Donor Research and Recruitment 
      Program, Georgetown University Medical Center, Washington, DC 20057, USA.
FAU - Xiao, Y
AU  - Xiao Y
FAU - Masaberg, C
AU  - Masaberg C
FAU - Tu, B
AU  - Tu B
FAU - Ng, J
AU  - Ng J
FAU - Hurley, C K
AU  - Hurley CK
FAU - Posch, P E
AU  - Posch PE
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20100922
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - *Alleles
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Histocompatibility Antigens Class II/*genetics
MH  - *Histocompatibility Testing
MH  - Humans
MH  - *Registries
EDAT- 2010/09/24 06:00
MHDA- 2011/05/27 06:00
CRDT- 2010/09/24 06:00
PHST- 2010/09/24 06:00 [entrez]
PHST- 2010/09/24 06:00 [pubmed]
PHST- 2011/05/27 06:00 [medline]
AID - 10.1111/j.1399-0039.2010.01558.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2011 Jan;77(1):54-61. doi: 10.1111/j.1399-0039.2010.01558.x. 
      Epub 2010 Sep 22.