PMID- 20860586
OWN - NLM
STAT- MEDLINE
DCOM- 20110218
LR  - 20101109
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 76
IP  - 6
DP  - 2010 Dec
TI  - Genetic differentiation of Jewish populations.
PG  - 442-58
LID - 10.1111/j.1399-0039.2010.01549.x [doi]
AB  - The Jewish diaspora can be viewed as a natural process in population dispersion 
      and differentiation. We extend genetic studies on the Jewish diaspora to an 
      analysis of human leukocyte antigen (HLA) haplotype distributions in the Jewish 
      peoples, and show the value of this information for the design of Jewish marrow 
      donor registries. HLA data from the Hadassah Bone Marrow Registry having parental 
      country-of-origin information comprise samples of geographically discrete 
      regions. We analyzed the HLA allele and haplotype frequencies for each national 
      sample using population genetic and clustering methods. Population 
      differentiation among diaspora populations was shown on the basis of HLA 
      haplotype frequencies, including differences within the more recently diverged 
      European groups. A method of haplotype and population clustering showed patterns 
      of unique haplotype affinities associated with specific Jewish populations. The 
      evidence showed that diaspora Jewish populations can be sorted into distinct 
      clades of which the Ashkenazi are but one. Relationships among Jewish populations 
      are interpretable in light of the historical record. We suggest that a major 
      contributing factor to the genetic divergence between Jewish groups may have been 
      admixture with local host populations, while, at the same time, threads of 
      Eastern Mediterranean ancestry remain evident.
CI  - (c) 2010 John Wiley & Sons A/S.
FAU - Klitz, W
AU  - Klitz W
AD  - School of Public Health, University of California, Berkeley, CA 94720-7360, USA. 
      klitz@berkeley.edu
FAU - Gragert, L
AU  - Gragert L
FAU - Maiers, M
AU  - Maiers M
FAU - Fernandez-Vina, M
AU  - Fernandez-Vina M
FAU - Ben-Naeh, Y
AU  - Ben-Naeh Y
FAU - Benedek, G
AU  - Benedek G
FAU - Brautbar, C
AU  - Brautbar C
FAU - Israel, S
AU  - Israel S
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20100922
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Female
MH  - Genetics, Medical/methods
MH  - HLA Antigens/*genetics/immunology
MH  - Haplotypes
MH  - Humans
MH  - Jews/*genetics
MH  - Male
EDAT- 2010/09/24 06:00
MHDA- 2011/02/22 06:00
CRDT- 2010/09/24 06:00
PHST- 2010/09/24 06:00 [entrez]
PHST- 2010/09/24 06:00 [pubmed]
PHST- 2011/02/22 06:00 [medline]
AID - 10.1111/j.1399-0039.2010.01549.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2010 Dec;76(6):442-58. doi: 10.1111/j.1399-0039.2010.01549.x. 
      Epub 2010 Sep 22.