PMID- 20861127
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20161125
IS  - 1879-0844 (Electronic)
IS  - 1388-9842 (Linking)
VI  - 12
IP  - 12
DP  - 2010 Dec
TI  - Prognosis of heart failure patients with reduced and preserved ejection fraction 
      and coexistent chronic obstructive pulmonary disease.
PG  - 1339-44
LID - 10.1093/eurjhf/hfq157 [doi]
AB  - AIMS: The long-term prognosis of patients with heart failure with preserved left 
      ventricular ejection fraction (HFPEF) and coexistent chronic obstructive 
      pulmonary disease (COPD) has not been previously investigated. The primary aim of 
      this study was to determine whether the long-term prognosis of HFPEF patients 
      with COPD differs from that of heart failure patients with reduced left 
      ventricular ejection fraction (HFREF) and COPD. The secondary aim was to identify 
      independent predictors of event-free survival in patients with HF and COPD. 
      METHODS AND RESULTS: We investigated 184 patients with coexistent HF and COPD. 
      Heart failure with preserved left ventricular ejection fraction was present in 98 
      cases (53%) and HFREF in the remaining 86 cases (47%). Mean follow-up time was 
      731+/-369 days. Cardiovascular/pulmonary hospitalization or mortality occurred in 
      71 patients (39%). No significant difference was observed between the two study 
      groups in terms of event-free survival (P=0.457), but event-free survival was 
      found to be independently associated with New York Heart Association (NYHA) class 
      [III vs. I, hazard ratio (HR) 2.92, 95% confidence interval (CI) 1.09-7.82], 
      Global initiative for chronic Obstructive Lung Disease (GOLD) stage (III vs. I, 
      HR 3.20, 95% CI 1.33-7.68), systemic hypertension (SHT; HR 2.99, 95% CI 
      1.41-6.33), and pulmonary hypertension (PH; HR 4.35, 95% CI 1.95-9.68). 
      CONCLUSION: In HF patients with coexisting COPD, cardiovascular and pulmonary 
      event-free survival of HFPEF was found to be similar to that of HFREF over 3 
      years follow-up. Furthermore, severe NYHA class, severe GOLD stage, SHT, and PH 
      were found to be independent predictors of event-free survival.
FAU - Kwon, Beom-June
AU  - Kwon BJ
AD  - Division of Cardiology, Department of Internal Medicine, College of Medicine, The 
      Catholic University of Korea, Seoul 130-709, Republic of Korea.
FAU - Kim, Dong-Bin
AU  - Kim DB
FAU - Jang, Sung-Won
AU  - Jang SW
FAU - Yoo, Ki-Dong
AU  - Yoo KD
FAU - Moon, Keun-Woong
AU  - Moon KW
FAU - Shim, Byung Ju
AU  - Shim BJ
FAU - Ahn, Seo-Hee
AU  - Ahn SH
FAU - Cho, Eun-Ju
AU  - Cho EJ
FAU - Rho, Tae-Ho
AU  - Rho TH
FAU - Kim, Jae-Hyung
AU  - Kim JH
LA  - eng
PT  - Journal Article
DEP - 20100922
PL  - England
TA  - Eur J Heart Fail
JT  - European journal of heart failure
JID - 100887595
SB  - IM
MH  - Aged
MH  - Comorbidity
MH  - Confidence Intervals
MH  - Female
MH  - Forced Expiratory Volume
MH  - Health Status Indicators
MH  - Heart Failure/diagnostic imaging/mortality/*pathology
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Korea/epidemiology
MH  - Logistic Models
MH  - Male
MH  - Multivariate Analysis
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Pulmonary Disease, Chronic Obstructive/diagnostic imaging/*pathology
MH  - Retrospective Studies
MH  - *Stroke Volume
MH  - Time Factors
MH  - Ultrasonography
MH  - *Ventricular Function, Left
EDAT- 2010/09/24 06:00
MHDA- 2011/06/03 06:00
CRDT- 2010/09/24 06:00
PHST- 2010/09/24 06:00 [entrez]
PHST- 2010/09/24 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
AID - hfq157 [pii]
AID - 10.1093/eurjhf/hfq157 [doi]
PST - ppublish
SO  - Eur J Heart Fail. 2010 Dec;12(12):1339-44. doi: 10.1093/eurjhf/hfq157. Epub 2010 
      Sep 22.