PMID- 20861135
OWN - NLM
STAT- MEDLINE
DCOM- 20110621
LR  - 20161125
IS  - 1879-0844 (Electronic)
IS  - 1388-9842 (Linking)
VI  - 12
IP  - 10
DP  - 2010 Oct
TI  - Granulocyte colony-stimulating factor attenuates left ventricular remodelling 
      after acute anterior STEMI: results of the single-blind, randomized, 
      placebo-controlled multicentre STem cEll Mobilization in Acute Myocardial 
      Infarction (STEM-AMI) Trial.
PG  - 1111-21
LID - 10.1093/eurjhf/hfq150 [doi]
AB  - AIMS: The aim of this study was to assess the effect of granulocyte 
      colony-stimulating factor (G-CSF) on left ventricular (LV) function and volumes 
      in patients with anterior ST-elevation myocardial infarction (STEMI) and 
      depressed LV ejection fraction (EF). METHODS AND RESULTS: Sixty consecutive 
      patients with anterior STEMI, undergoing primary angioplasty percutaneous 
      coronary intervention (PCI), with symptom-to-reperfusion time of 2-12 h and EF 
      </=45% after PCI, were randomized to G-CSF 5 mug/kg b.i.d. subcutaneously (n = 24) 
      or placebo (n = 25) for 5 days, starting <12 h after PCI. The primary endpoint 
      was an increase from baseline to 6 months of 5% in left ventricular ejection 
      fraction (LVEF), as measured by magnetic resonance imaging (MRI). Co-primary 
      endpoint was a >/=20 mL difference in end-diastolic volume (EDV). Infarct size and 
      perfusion were evaluated with late gadolinium enhancement (LGE) and gated 
      (99m)Technetium Sestamibi single-photon emission computed tomography (SPECT). 
      Left ventricular EDV and end-systolic volume (ESV) increased from baseline to 6 
      months in the placebo group (81.7 +/- 24.4 to 94.4 +/- 26.0 mL/m(2), P < 0.00005 and 
      45.2 +/- 20.0 to 53.2 +/- 23.8 mL/m(2), P = 0.016) but were unchanged in the G-CSF 
      group (82.2 +/- 20.3 to 85.7 +/- 23.7 mL/m(2), P = 0.40 and 46.0 +/- 18.2 to 48.4 +/- 
      20.8 mL/m(2), P = 0.338). There were no significant differences in EF or 
      perfusion between groups. A significant reduction in transmural LGE segments was 
      seen at 6 months in the G-CSF vs. placebo groups (4.38 +/- 2.9 to 3.3 +/- 2.6, P = 
      0.04 and 4.2 +/- 2.6 to 3.6 +/- 2.7, P = 0.301, respectively). Significantly more 
      placebo patients had a change in left ventricular end-diastolic volume abovethe 
      median (9.3 mL/m(2)) when reperfusion time exceeded 180 min (median 
      time-to-reperfusion) (P = 0.0123). Severe adverse events were similar between 
      groups. CONCLUSION: Early G-CSF administration attenuates ventricular remodelling 
      in patients with anterior STEMI and EF </=45% after successful PCI.
FAU - Achilli, Felice
AU  - Achilli F
AD  - Cardiology Department, A. Manzoni Hospital, via dell'Eremo 9/11, 23900 Lecco, 
      Italy. f.achilli@ospedale.lecco.it
FAU - Malafronte, Cristina
AU  - Malafronte C
FAU - Lenatti, Laura
AU  - Lenatti L
FAU - Gentile, Francesco
AU  - Gentile F
FAU - Dadone, Viola
AU  - Dadone V
FAU - Gibelli, Giuseppe
AU  - Gibelli G
FAU - Maggiolini, Stefano
AU  - Maggiolini S
FAU - Squadroni, Lidia
AU  - Squadroni L
FAU - Di Leo, Claudio
AU  - Di Leo C
FAU - Burba, Ilaria
AU  - Burba I
FAU - Pesce, Maurizio
AU  - Pesce M
FAU - Mircoli, Luca
AU  - Mircoli L
FAU - Capogrossi, Maurizio C
AU  - Capogrossi MC
FAU - Di Lelio, Alessandro
AU  - Di Lelio A
FAU - Camisasca, Paola
AU  - Camisasca P
FAU - Morabito, Alberto
AU  - Morabito A
FAU - Colombo, Gualtiero
AU  - Colombo G
FAU - Pompilio, Giulio
AU  - Pompilio G
CN  - STEM-AMI Investigators
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur J Heart Fail
JT  - European journal of heart failure
JID - 100887595
RN  - 143011-72-7 (Granulocyte Colony-Stimulating Factor)
SB  - IM
CIN - Eur J Heart Fail. 2010 Oct;12(10):1021-3. PMID: 20861130
MH  - Analysis of Variance
MH  - Angioplasty, Balloon, Coronary
MH  - Female
MH  - Granulocyte Colony-Stimulating Factor/*therapeutic use
MH  - Heart Ventricles/diagnostic imaging/pathology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/diagnostic imaging/*drug therapy/pathology
MH  - Myocardial Reperfusion
MH  - Single-Blind Method
MH  - *Stem Cells
MH  - Stroke Volume
MH  - Tomography, Emission-Computed, Single-Photon
MH  - Ultrasonography
MH  - Ventricular Function, Left
MH  - *Ventricular Remodeling
EDAT- 2010/09/24 06:00
MHDA- 2011/06/22 06:00
CRDT- 2010/09/24 06:00
PHST- 2010/09/24 06:00 [entrez]
PHST- 2010/09/24 06:00 [pubmed]
PHST- 2011/06/22 06:00 [medline]
AID - hfq150 [pii]
AID - 10.1093/eurjhf/hfq150 [doi]
PST - ppublish
SO  - Eur J Heart Fail. 2010 Oct;12(10):1111-21. doi: 10.1093/eurjhf/hfq150.