PMID- 20861617
OWN - NLM
STAT- MEDLINE
DCOM- 20110324
LR  - 20220311
IS  - 1421-9735 (Electronic)
IS  - 0253-5068 (Linking)
VI  - 30
IP  - 3
DP  - 2010
TI  - Sevelamer carbonate reduces inflammation and endotoxemia in an animal model of 
      uremia.
PG  - 153-8
LID - 10.1159/000319850 [doi]
AB  - BACKGROUND: Renal failure is associated with activation of inflammatory response, 
      but the mechanisms behind this observation and potential anti-inflammatory 
      strategies are yet to be defined. Endotoxin (ET) translocation from the 
      intestinal lumen can potentially trigger systemic inflammatory response, and ET 
      binding represents a potential anti-inflammatory strategy in renal failure. The 
      aim of this study was to evaluate the ET-binding capacity of sevelamer carbonate 
      in an animal model of renal failure. MATERIAL AND METHODS: Rats were 5/6 
      nephrectomized to induce uremia (U) and sham-operated rats were allocated to 
      receive normal chow (controls) or a diet with 3% sevelamer carbonate added (+SC) 
      for 60 days. Tumor necrosis factor-alpha (TNF-alpha) and ET were measured in plasma on 
      days 7, 30 and 60 in all animals. RESULTS: Renal failure induced an inflammatory 
      response, since TNF-alpha levels were undetectable in all control animals in contrast 
      to the uremic group (3.18 +/- 0.62, 2.58 +/- 0.54 and 1.86 +/- 0.47 pg/ml, 
      respectively, on days 7, 30 and 60; p < 0.05 at all time points). Similarly, 
      uremic rats presented an increase in ET levels (0.038 +/- 0.007 EU/ml) when 
      compared to sham-operated animals (0.008 +/- 0.006 EU/ml; p < 0.05). During the 
      study, TNF-alpha levels in U + SC rats were significantly lower compared with 
      U-control animals (p < 0.05). Similarly, ET levels in U + SC rats were lower when 
      compared with U-control rats (p < 0.005). CONCLUSION: In conclusion, induction of 
      renal failure triggered inflammation and induced endotoxemia in this experimental 
      model of chronic kidney disease, which were reduced by sevelamer treatment. This 
      data suggests that sevelamer carbonate induces an anti-inflammatory effect in 
      parallel to a reduction in ET.
CI  - Copyright (c) 2010 S. Karger AG, Basel.
FAU - Hauser, Aline B
AU  - Hauser AB
AD  - Center for Health and Biological Sciences, Pontificia Universidade Catolica do 
      Parana, Rua Imaculada Conceicao 1155, Curitiba, Brazil.
FAU - Azevedo, Iuly R F
AU  - Azevedo IR
FAU - Goncalves, Simone
AU  - Goncalves S
FAU - Stinghen, Andrea
AU  - Stinghen A
FAU - Aita, Carlos
AU  - Aita C
FAU - Pecoits-Filho, Roberto
AU  - Pecoits-Filho R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100921
PL  - Switzerland
TA  - Blood Purif
JT  - Blood purification
JID - 8402040
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Polyamines)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9YCX42I8IU (Sevelamer)
SB  - IM
CIN - Blood Purif. 2010;30(3):159-60. PMID: 20861618
MH  - Animals
MH  - Anti-Inflammatory Agents/therapeutic use
MH  - Endotoxemia/*prevention & control
MH  - Inflammation/complications/*drug therapy
MH  - Kidney Failure, Chronic/complications
MH  - Models, Animal
MH  - Polyamines/*therapeutic use
MH  - Rats
MH  - Renal Insufficiency, Chronic/complications
MH  - Sevelamer
MH  - Tumor Necrosis Factor-alpha/biosynthesis
MH  - Uremia/*drug therapy
EDAT- 2010/09/24 06:00
MHDA- 2011/03/25 06:00
CRDT- 2010/09/24 06:00
PHST- 2010/03/15 00:00 [received]
PHST- 2010/06/19 00:00 [accepted]
PHST- 2010/09/24 06:00 [entrez]
PHST- 2010/09/24 06:00 [pubmed]
PHST- 2011/03/25 06:00 [medline]
AID - 000319850 [pii]
AID - 10.1159/000319850 [doi]
PST - ppublish
SO  - Blood Purif. 2010;30(3):153-8. doi: 10.1159/000319850. Epub 2010 Sep 21.