PMID- 20862566
OWN - NLM
STAT- MEDLINE
DCOM- 20120822
LR  - 20211020
IS  - 1559-131X (Electronic)
IS  - 1357-0560 (Linking)
VI  - 28 Suppl 1
DP  - 2011 Dec
TI  - Effect of apoptotic and proliferative indices, P-glycoprotein and survivin 
      expression on prognosis in laryngeal squamous cell carcinoma.
PG  - S333-40
LID - 10.1007/s12032-010-9686-x [doi]
AB  - This study was to explore the relationship between P-glycoprotein and survivin 
      expression with apoptotic index, proliferative index, clinicopathologic 
      characteristics, and their prognostic value in laryngeal squamous cell carcinoma 
      (LSCC). Samples from 86 patients with LSCC were analyzed for P-glycoprotein, 
      survivin, and Ki-67 expression by immunohistochemistry and apoptotic index by the 
      TUNEL method. The association of P-glycoprotein and survivin expression with 
      clinicopathologic parameters, apoptotic and proliferative activities, and 
      patients' overall survival was subsequently analyzed. We found that up-regulation 
      of P-glycoprotein expression was associated with decreased apoptosis but not with 
      changes in proliferation, whereas increased survivin expression was correlated 
      with decreased apoptosis and increased proliferation. There was a positive 
      correlation between P-glycoprotein and survivin expression. Expression of these 
      two proteins was significantly related to the clinical stage, histological grade, 
      lymph node metastasis, and overall survival in LSCC. These results reveal that 
      survivin and P-glycoprotein may have an effect on chemotherapy resistance and 
      progression of LSCC through promoting proliferation and/or suppressing apoptosis. 
      Furthermore, our results demonstrate that P-glycoprotein and survivin proteins 
      are both predictive of malignant progression and prognosis of LSCC.
FAU - Li, Da-Wei
AU  - Li DW
AD  - Department of Otolaryngology-Head & Neck Surgery, Shanghai Jiaotong University 
      Affiliated First People's Hospital, 200080 Shanghai, China.
FAU - Gao, Shang
AU  - Gao S
FAU - Shen, Bin
AU  - Shen B
FAU - Dong, Pin
AU  - Dong P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100923
PL  - United States
TA  - Med Oncol
JT  - Medical oncology (Northwood, London, England)
JID - 9435512
RN  - 0 (ABCB1 protein, human)
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B)
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B, Member 1)
RN  - 0 (BIRC5 protein, human)
RN  - 0 (Inhibitor of Apoptosis Proteins)
RN  - 0 (Survivin)
SB  - IM
MH  - ATP Binding Cassette Transporter, Subfamily B
MH  - ATP Binding Cassette Transporter, Subfamily B, Member 1/*metabolism
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Apoptosis
MH  - Carcinoma, Squamous Cell/diagnosis/*metabolism/mortality
MH  - Cell Proliferation
MH  - Female
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Inhibitor of Apoptosis Proteins/*metabolism
MH  - Laryngeal Neoplasms/diagnosis/*metabolism/mortality
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Survival Rate
MH  - Survivin
MH  - Treatment Outcome
EDAT- 2010/09/24 06:00
MHDA- 2012/08/23 06:00
CRDT- 2010/09/24 06:00
PHST- 2010/08/31 00:00 [received]
PHST- 2010/09/09 00:00 [accepted]
PHST- 2010/09/24 06:00 [entrez]
PHST- 2010/09/24 06:00 [pubmed]
PHST- 2012/08/23 06:00 [medline]
AID - 10.1007/s12032-010-9686-x [doi]
PST - ppublish
SO  - Med Oncol. 2011 Dec;28 Suppl 1:S333-40. doi: 10.1007/s12032-010-9686-x. Epub 2010 
      Sep 23.