PMID- 20864097
OWN - NLM
STAT- MEDLINE
DCOM- 20110121
LR  - 20220419
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Linking)
VI  - 95
IP  - 1
DP  - 2011 Jan
TI  - Complex chromosomal rearrangements in infertile males: complexity of 
      rearrangement affects spermatogenesis.
PG  - 349-52, 352.e1-5
LID - 10.1016/j.fertnstert.2010.08.014 [doi]
AB  - In this report, we describe 10 male cases of complex chromosome rearrangements 
      (CCRs) with fertility problems: seven of them showed impairment of 
      spermatogenesis, oligoasthenoteratozoospermia or azoospermia; in the other three 
      cases, recurrent abortions were observed. The CCRs were characterized by 
      conventional fluorescence in situ hybridization (FISH) and multicolor FISH 
      methods as well as by the routine G-banding technique. CCRs found in three cases 
      with recurrent abortions were double two-way exchanges, which were the simplest 
      forms of CCRs; three oligoastenoteratozoospermic cases were double two-way 
      exchanges or three-way exchanges. However, the CCRs in four azoospermic cases 
      were much more complicated forms of CCRs. From our results and a review of the 
      literature, we conclude that the complexity of CCRs might affect the severity of 
      spermatogenetic impairment rather than the number of chromosomes involved or the 
      location of breakpoints.
CI  - Copyright (c) 2011 American Society for Reproductive Medicine. Published by 
      Elsevier Inc. All rights reserved.
FAU - Kim, Ji Won
AU  - Kim JW
AD  - Department of Obstetrics and Gynecology, Fertility Center of CHA Gangnam Medical 
      Center, CHA University, Seoul, South Korea.
FAU - Chang, Eun Mi
AU  - Chang EM
FAU - Song, Seung-Hun
AU  - Song SH
FAU - Park, Sang Hee
AU  - Park SH
FAU - Yoon, Tae Ki
AU  - Yoon TK
FAU - Shim, Sung Han
AU  - Shim SH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
RN  - Male sterility due to Y-chromosome deletions
SB  - IM
MH  - Azoospermia/*genetics/pathology
MH  - Biopsy
MH  - *Chromosome Aberrations
MH  - Chromosome Breakpoints
MH  - Chromosome Deletion
MH  - Chromosomes, Human, Y/genetics
MH  - Gene Rearrangement/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infertility, Male
MH  - Male
MH  - Oligospermia/*genetics/pathology
MH  - Sex Chromosome Aberrations
MH  - Sex Chromosome Disorders of Sex Development/genetics
MH  - Spermatogenesis/*genetics
MH  - Testis/pathology
EDAT- 2010/09/25 06:00
MHDA- 2011/01/22 06:00
CRDT- 2010/09/25 06:00
PHST- 2010/03/30 00:00 [received]
PHST- 2010/07/09 00:00 [revised]
PHST- 2010/08/09 00:00 [accepted]
PHST- 2010/09/25 06:00 [entrez]
PHST- 2010/09/25 06:00 [pubmed]
PHST- 2011/01/22 06:00 [medline]
AID - S0015-0282(10)02296-X [pii]
AID - 10.1016/j.fertnstert.2010.08.014 [doi]
PST - ppublish
SO  - Fertil Steril. 2011 Jan;95(1):349-52, 352.e1-5. doi: 
      10.1016/j.fertnstert.2010.08.014.