PMID- 20864319
OWN - NLM
STAT- MEDLINE
DCOM- 20110323
LR  - 20211020
IS  - 0165-1781 (Print)
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 184
IP  - 2
DP  - 2010 Nov 30
TI  - Reduced medial prefrontal N-acetyl-aspartate levels in pediatric major depressive 
      disorder: a multi-voxel in vivo(1)H spectroscopy study.
PG  - 71-6
LID - 10.1016/j.pscychresns.2010.07.008 [doi]
AB  - There is increasing evidence of a reciprocal fronto-limbic network in the 
      pathogenesis of mood disorders. Prior in vivo proton ((1)H) spectroscopy studies 
      provide evidence of abnormal neurochemical levels in the cingulate and 
      dorsolateral prefrontal cortex (DLPFC) of adult subjects with major depressive 
      disorder (MDD). We examined whether similar abnormalities occur in children and 
      adolescents with MDD. We collected two-dimensional multi-voxel in vivo (1)H 
      spectroscopy data at 1.5 Tesla to quantify levels of N-acetyl-aspartate (NAA), 
      glycerolphosphocholine plus phosphocholine (GPC+PC), and phosphocreatine plus 
      creatine (PCr+Cr) in the DLPFC, medial prefrontal cortex (MPFC), and anterior 
      cingulate (AC) of children and adolescents aged 8-17 years with MDD (n=16) 
      compared with healthy control subjects (n=38). Analysis of covariance with age 
      and gender as covariates was performed. MDD subjects showed significantly lower 
      levels of NAA in the right MPFC and right AC than controls. MDD subjects also had 
      significantly lower levels of GPC+PC in the right AC than control subjects. There 
      were no significant differences in other metabolites in the studied regions. 
      Pediatric patients with MDD exhibit neurochemical alterations in prefrontal 
      cortex regions that are important in the monitoring and regulation of emotional 
      states.
CI  - Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Olvera, Rene Luis
AU  - Olvera RL
AD  - Department of Psychiatry, The University of Texas Health Science Center, San 
      Antonio, TX, USA. olverar@UTHSCSA.edu
FAU - Caetano, Sheila C
AU  - Caetano SC
FAU - Stanley, Jeffrey A
AU  - Stanley JA
FAU - Chen, Hua-Hsuan
AU  - Chen HH
FAU - Nicoletti, Mark
AU  - Nicoletti M
FAU - Hatch, John P
AU  - Hatch JP
FAU - Fonseca, Manoela
AU  - Fonseca M
FAU - Pliszka, Steven R
AU  - Pliszka SR
FAU - Soares, Jair C
AU  - Soares JC
LA  - eng
GR  - M01-RR-01346/RR/NCRR NIH HHS/United States
GR  - K24 RR020571-01A1/RR/NCRR NIH HHS/United States
GR  - R01 MH069774/MH/NIMH NIH HHS/United States
GR  - K23 MH068280-01A1/MH/NIMH NIH HHS/United States
GR  - R01 MH069774-01A2/MH/NIMH NIH HHS/United States
GR  - K23 MH068280/MH/NIMH NIH HHS/United States
GR  - RR020571/RR/NCRR NIH HHS/United States
GR  - MH69774/MH/NIMH NIH HHS/United States
GR  - M01 RR001346/RR/NCRR NIH HHS/United States
GR  - K24 RR020571/RR/NCRR NIH HHS/United States
GR  - K23-MH068280/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - 020IUV4N33 (Phosphocreatine)
RN  - 107-73-3 (Phosphorylcholine)
RN  - 30KYC7MIAI (Aspartic Acid)
RN  - 997-55-7 (N-acetylaspartate)
RN  - MU72812GK0 (Creatine)
SB  - IM
MH  - Adolescent
MH  - Affect
MH  - Aspartic Acid/*analogs & derivatives/analysis/metabolism
MH  - Brain Mapping
MH  - Child
MH  - Creatine/analysis/metabolism
MH  - Depressive Disorder, Major/*metabolism
MH  - Female
MH  - Gyrus Cinguli/chemistry/*metabolism
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Spectroscopy/methods
MH  - Male
MH  - Phosphocreatine/analysis
MH  - Phosphorylcholine/analysis/metabolism
MH  - Prefrontal Cortex/chemistry/*metabolism
PMC - PMC2963721
MID - NIHMS227814
EDAT- 2010/09/25 06:00
MHDA- 2011/03/24 06:00
PMCR- 2011/11/30
CRDT- 2010/09/25 06:00
PHST- 2009/07/21 00:00 [received]
PHST- 2010/05/10 00:00 [revised]
PHST- 2010/07/27 00:00 [accepted]
PHST- 2010/09/25 06:00 [entrez]
PHST- 2010/09/25 06:00 [pubmed]
PHST- 2011/03/24 06:00 [medline]
PHST- 2011/11/30 00:00 [pmc-release]
AID - S0925-4927(10)00262-3 [pii]
AID - 10.1016/j.pscychresns.2010.07.008 [doi]
PST - ppublish
SO  - Psychiatry Res. 2010 Nov 30;184(2):71-6. doi: 10.1016/j.pscychresns.2010.07.008.