PMID- 20864797
OWN - NLM
STAT- MEDLINE
DCOM- 20110718
LR  - 20101130
IS  - 1440-1592 (Electronic)
IS  - 1323-8930 (Linking)
VI  - 59
IP  - 4
DP  - 2010 Dec
TI  - Development of IL-17-mediated delayed-type hypersensitivity is not affected by 
      down-regulation of IL-25 expression.
PG  - 399-408
LID - 10.2332/allergolint.10-OA-0218 [doi]
AB  - BACKGROUND: IL-25, which is a member of the IL-17 family, induces Th2 cell 
      differentiation and Th2 cytokine production, contributing to induction of 
      Th2-type immune responses and diseases, as a result of which it suppresses Th1- 
      and Th17-type immune responses. METHODS: To elucidate the role of IL-25 in the 
      pathogenesis of IL-17-mediated delayed-type hypersensitivity (DTH), 
      IL-25-deficient mice were sensitized with methylated BSA (mBSA), and then a DTH 
      reaction was induced by mBSA challenge. mBSA-specific T-cell induction was 
      assessed on the basis of cell proliferation and cytokine production. The DTH 
      reaction was evaluated on the basis of tissue swelling, histology and 
      inflammatory mediator expression. RESULTS: IL-25 expression was markedly reduced 
      in local DTH lesions. However, mBSA-specific Th1, Th2 and Th17 cell induction, 
      and the mBSA-induced DTH reaction were comparable in IL-25-deficient and 
      wild-type mice. CONCLUSIONS: IL-25 is not essential for differentiation of Th1, 
      Th2 and Th17 cells in the sensitization phase or induction of local inflammation 
      in the elicitation phase of the mBSA-induced DTH reaction.
FAU - Ishii, Akina
AU  - Ishii A
AD  - Department of Allergy and Immunology, National Research Institute for Child 
      Health and Development, Tokyo, Japan.
FAU - Oboki, Keisuke
AU  - Oboki K
FAU - Nambu, Aya
AU  - Nambu A
FAU - Morita, Hideaki
AU  - Morita H
FAU - Ohno, Tatsukuni
AU  - Ohno T
FAU - Kajiwara, Naoki
AU  - Kajiwara N
FAU - Arae, Ken
AU  - Arae K
FAU - Sudo, Hajime
AU  - Sudo H
FAU - Okumura, Ko
AU  - Okumura K
FAU - Saito, Hirohisa
AU  - Saito H
FAU - Nakae, Susumu
AU  - Nakae S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100925
PL  - England
TA  - Allergol Int
JT  - Allergology international : official journal of the Japanese Society of 
      Allergology
JID - 9616296
RN  - 0 (IL25 protein, human)
RN  - 0 (Interleukin-17)
SB  - IM
MH  - Animals
MH  - Cell Proliferation
MH  - Cells, Cultured
MH  - Down-Regulation
MH  - Hypersensitivity, Delayed/*immunology
MH  - Immunization
MH  - Interleukin-17/genetics/immunology/*metabolism
MH  - Lymphocyte Activation
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Knockout
MH  - Th17 Cells/immunology/*metabolism/pathology
MH  - Th2 Cells/immunology/*metabolism/pathology
EDAT- 2010/09/25 06:00
MHDA- 2011/07/19 06:00
CRDT- 2010/09/25 06:00
PHST- 2010/04/20 00:00 [received]
PHST- 2010/05/17 00:00 [accepted]
PHST- 2010/09/25 06:00 [entrez]
PHST- 2010/09/25 06:00 [pubmed]
PHST- 2011/07/19 06:00 [medline]
AID - S1323-8930(15)30652-3 [pii]
AID - 10.2332/allergolint.10-OA-0218 [doi]
PST - ppublish
SO  - Allergol Int. 2010 Dec;59(4):399-408. doi: 10.2332/allergolint.10-OA-0218. Epub 
      2010 Sep 25.