PMID- 20865453
OWN - NLM
STAT- MEDLINE
DCOM- 20120404
LR  - 20220331
IS  - 1522-1709 (Electronic)
IS  - 1520-9512 (Linking)
VI  - 15
IP  - 4
DP  - 2011 Dec
TI  - Effects of obstructive sleep apnea on serum brain-derived neurotrophic factor 
      protein, cortisol, and lipid levels.
PG  - 649-56
LID - 10.1007/s11325-010-0415-7 [doi]
AB  - OBJECTIVES: Obstructive sleep apnea (OSA) is a sleep-disordered breathing leading 
      to vascular endothelial cells dysfunction, cognitive impairment, and abnormal 
      lipid metabolism. serum brain-derived neurotrophic factor (BDNF) protein, 
      cortisol, and lipid levels in OSA were investigated. MATERIALS AND METHODS: All 
      middle-aged subjects including healthy individuals without signs and symptoms of 
      apnea-hypopnea and ear nose throat (ENT) outpatients were randomly recruited and 
      screened by overnight polysomnogram (PSG). Apnea-hypopnea index (AHI) was used as 
      a criteria to determine subjects to enroll in this program. According to AHI, 
      they were separated into control and OSA groups. A group of 39 OSA patients (AHI 
      >/= 10 events/h) and 24 control subjects (AHI < 5 events/h) were selected. Serum 
      BDNF protein was analyzed by enzyme-linked immunosorbent assay (ELISA) from 
      venous blood collection at 8:00 a.m. following PSG. Serum cortisol was assayed by 
      enzyme-chemiluminescense immuno assay (ECLIA). Serum lipid profile levels were 
      determined by enzymatic colorimetric and homogeneous method. RESULTS: 
      Characteristics of OSA patients and control groups including gender, age, AHI, 
      body weight, height, and BMI showed significant differences. Serum BDNF protein, 
      cortisol, triglyceride, and total cholesterol levels in OSA and control groups 
      were not significantly different. High density lipoprotein-cholesterol (HDL-c) in 
      OSA was significantly lower than that of control (p = 0.008) while low density 
      lipoprotein-cholesterol (LDL-c) was significantly higher than that of control (p 
      = 0.04). CONCLUSIONS: OSA had no significant effect on serum BDNF, cortisol, 
      triglyceride, or total cholesterol levels while LDL-c and HDL-c levels in OSA 
      patients compared to control were significantly different at p = 0.04, and p = 
      0.008, respectively.
FAU - Panaree, Busarakumtragul
AU  - Panaree B
AD  - Department of Physiology, Faculty of Medicine, Srinakharinwirot University, 
      Bangkok 10110, Thailand. panaree@swu.ac.th
FAU - Chantana, Mekseepralard
AU  - Chantana M
FAU - Wasana, Sukhumsirichart
AU  - Wasana S
FAU - Chairat, Neruntarat
AU  - Chairat N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100924
PL  - Germany
TA  - Sleep Breath
JT  - Sleep & breathing = Schlaf & Atmung
JID - 9804161
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Lipids)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Academic Medical Centers
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Female
MH  - Humans
MH  - Hydrocortisone/*blood
MH  - Lipids/*blood
MH  - Male
MH  - Middle Aged
MH  - Polysomnography
MH  - Reference Values
MH  - Sleep Apnea, Obstructive/*blood/diagnosis
MH  - Thailand
EDAT- 2010/09/25 06:00
MHDA- 2012/04/05 06:00
CRDT- 2010/09/25 06:00
PHST- 2010/03/22 00:00 [received]
PHST- 2010/09/06 00:00 [accepted]
PHST- 2010/07/31 00:00 [revised]
PHST- 2010/09/25 06:00 [entrez]
PHST- 2010/09/25 06:00 [pubmed]
PHST- 2012/04/05 06:00 [medline]
AID - 10.1007/s11325-010-0415-7 [doi]
PST - ppublish
SO  - Sleep Breath. 2011 Dec;15(4):649-56. doi: 10.1007/s11325-010-0415-7. Epub 2010 
      Sep 24.