PMID- 20865740
OWN - NLM
STAT- MEDLINE
DCOM- 20120824
LR  - 20181201
IS  - 1098-1063 (Electronic)
IS  - 1050-9631 (Linking)
VI  - 21
IP  - 9
DP  - 2011 Sep
TI  - Cholinergic hypofunction impairs memory acquisition possibly through hippocampal 
      Arc and BDNF downregulation.
PG  - 999-1009
LID - 10.1002/hipo.20812 [doi]
AB  - Recent evidence suggests that activity-regulated cytoskeleton associated protein 
      (Arc) and brain-derived neurotrophic factor (BDNF) are key players in the 
      cellular mechanisms that trigger synaptic changes and memory consolidation. 
      Cholinergic deafferentiation of hippocampus has been largely shown to induce 
      memory impairments in different behavioral tasks. However, the mechanisms 
      underlying cholinergic-induced memory formation remain unclear. The role of 
      hippocampal cholinergic denervation on synaptic consolidation and further 
      acquisition of spatial memory was hereby examined by analyzing Arc and BDNF in 
      standard environment and after behavioral training in Morris water maze (MWM). In 
      standard environment, a cholinergic hypofunction induced by the toxin (192) 
      IgG-saporin led to significant decreases in Arc protein and mRNA as well as in 
      BDNF. Lesioned rats subjected to MWM showed a worse acquisition performance that 
      was reversed after galantamine treatment. Recovery of memory acquisition was 
      accompanied by normalization of Arc and BDNF levels in hippocampus. Stimulation 
      of muscarinic, but not nicotinic receptors, in hippocampal primary neurons caused 
      a rapid induction of Arc production. These data suggest that cholinergic 
      denervation of hippocampus leads to deficits in muscarinic-dependent induction of 
      Arc and a subsequent impairment of spatial memory acquisition.
CI  - Copyright (c) 2010 Wiley-Liss, Inc.
FAU - Gil-Bea, Francisco J
AU  - Gil-Bea FJ
AD  - Department of Neurobiology, Care Sciences and Society, Karolinska 
      Institutet-Alzheimer's Disease Research Center, Karolinska Institutet, Stockholm, 
      Sweden. Francisco.Gil-Bea@ki.se
FAU - Solas, Maite
AU  - Solas M
FAU - Mateos, Laura
AU  - Mateos L
FAU - Winblad, Bengt
AU  - Winblad B
FAU - Ramirez, Maria J
AU  - Ramirez MJ
FAU - Cedazo-Minguez, Angel
AU  - Cedazo-Minguez A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100602
PL  - United States
TA  - Hippocampus
JT  - Hippocampus
JID - 9108167
RN  - 0 (192 IgG-saporin)
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cholinesterase Inhibitors)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (Immunotoxins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Muscarinic)
RN  - 0 (Receptors, Nicotinic)
RN  - 0 (Ribosome Inactivating Proteins, Type 1)
RN  - 0 (activity regulated cytoskeletal-associated protein)
RN  - 0D3Q044KCA (Galantamine)
RN  - EC 3.2.2.22 (Saporins)
RN  - N9YNS0M02X (Acetylcholine)
SB  - IM
MH  - Acetylcholine/metabolism
MH  - Animals
MH  - Antibodies, Monoclonal/pharmacology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cholinergic Fibers/drug effects
MH  - Cholinesterase Inhibitors/pharmacology
MH  - Cytoskeletal Proteins/genetics/*metabolism
MH  - Female
MH  - Galantamine/pharmacology
MH  - Hippocampus/drug effects/*metabolism/surgery
MH  - Immunotoxins/pharmacology
MH  - Male
MH  - Maze Learning/*physiology
MH  - Memory/*physiology
MH  - Memory Disorders/metabolism
MH  - Nerve Tissue Proteins/genetics/*metabolism
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Rats, Wistar
MH  - Receptors, Muscarinic/*metabolism
MH  - Receptors, Nicotinic/metabolism
MH  - Ribosome Inactivating Proteins, Type 1/pharmacology
MH  - Saporins
EDAT- 2010/09/25 06:00
MHDA- 2012/08/25 06:00
CRDT- 2010/09/25 06:00
PHST- 2010/03/23 00:00 [accepted]
PHST- 2010/09/25 06:00 [entrez]
PHST- 2010/09/25 06:00 [pubmed]
PHST- 2012/08/25 06:00 [medline]
AID - 10.1002/hipo.20812 [doi]
PST - ppublish
SO  - Hippocampus. 2011 Sep;21(9):999-1009. doi: 10.1002/hipo.20812. Epub 2010 Jun 2.