PMID- 20865759
OWN - NLM
STAT- MEDLINE
DCOM- 20110203
LR  - 20211020
IS  - 1520-6300 (Electronic)
IS  - 1042-0533 (Print)
IS  - 1042-0533 (Linking)
VI  - 22
IP  - 6
DP  - 2010 Nov-Dec
TI  - Life history, immune function, and intestinal helminths: Trade-offs among 
      immunoglobulin E, C-reactive protein, and growth in an Amazonian population.
PG  - 836-48
LID - 10.1002/ajhb.21092 [doi]
AB  - OBJECTIVES: Infection with helminths is associated with shifts in host immunity, 
      including increased production of immunoglobulin E (IgE) and reduced 
      inflammation. Given limited energy budgets, these shifts may involve changes in 
      energy allocation toward competing demands. Here we test for potential trade-offs 
      between growth, IgE, and the inflammatory marker C-reactive protein (CRP). 
      METHODS: Dried blood spots and anthropometrics were collected from 162 Shuar 
      forager-horticulturalists from a village in southeastern Ecuador. Enzyme-linked 
      immunosorbent assays (ELISAs) were used to measure IgE and CRP. Relationships 
      among IgE, CRP, and anthropometrics were examined in three groups: children aged 
      2-7 years (n = 63), children aged 8-15 (n = 61), and adults over age 18 (n = 37). 
      RESULTS: Geometric mean IgE was 1,196 IU ml(-)(1) while geometric mean CRP was 1.33 
      mg l(-)(1). In children, IgE and CRP were negatively correlated (r = -0.21, P = 0.02, 
      df = 122). Controlling for fat stores and age, IgE was associated with lower 
      stature in children (t = -2.04, P = 0.04, df = 109), and adults (t = -3.29, P < 
      0.01, df = 33). In children there was a significant interaction between age and 
      CRP, such that in younger children CRP was associated with shorter stature, but 
      in older children was associated with greater stature (t = 2.15, P = 0.04, df = 
      109). CONCLUSIONS: These results suggest that infection with helminths may have 
      hidden costs associated with immunological changes, and that these costs may 
      ultimately affect growth and other life history parameters.
CI  - (c) 2010 Wiley-Liss, Inc.
FAU - Blackwell, Aaron D
AU  - Blackwell AD
AD  - Integrative Anthropological Sciences, University of California, Santa Barbara, 
      California 93106-3210, USA. ablackwell@isber.ucsb.edu
FAU - Snodgrass, J Josh
AU  - Snodgrass JJ
FAU - Madimenos, Felicia C
AU  - Madimenos FC
FAU - Sugiyama, Lawrence S
AU  - Sugiyama LS
LA  - eng
GR  - DP1 OD000516/OD/NIH HHS/United States
GR  - DP1 OD000516-04/OD/NIH HHS/United States
GR  - 5DP1O000516-04/DP/NCCDPHP CDC HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Am J Hum Biol
JT  - American journal of human biology : the official journal of the Human Biology 
      Council
JID - 8915029
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Body Weights and Measures
MH  - C-Reactive Protein/*analysis
MH  - Child
MH  - Child, Preschool
MH  - Ecuador/epidemiology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Growth/*physiology
MH  - Health Surveys
MH  - Helminthiasis/*complications/ethnology/immunology
MH  - Humans
MH  - Immunity
MH  - Immunoglobulin E/*blood
MH  - *Indians, South American
MH  - Male
PMC - PMC4512836
MID - NIHMS232863
EDAT- 2010/09/25 06:00
MHDA- 2011/02/04 06:00
PMCR- 2015/07/23
CRDT- 2010/09/25 06:00
PHST- 2010/09/25 06:00 [entrez]
PHST- 2010/09/25 06:00 [pubmed]
PHST- 2011/02/04 06:00 [medline]
PHST- 2015/07/23 00:00 [pmc-release]
AID - 10.1002/ajhb.21092 [doi]
PST - ppublish
SO  - Am J Hum Biol. 2010 Nov-Dec;22(6):836-48. doi: 10.1002/ajhb.21092.