PMID- 20869954
OWN - NLM
STAT- MEDLINE
DCOM- 20110923
LR  - 20101108
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1362
DP  - 2010 Nov 29
TI  - Z-Bisdehydrodoisynolic acid (Z-BDDA): an estrogenic seco-steroid that enhances 
      behavioral recovery following moderate fluid percussion brain injury in male 
      rats.
PG  - 93-101
LID - 10.1016/j.brainres.2010.09.055 [doi]
AB  - Several lines of research suggest that estrogens (and estrogenic compounds) are 
      neuroprotective following experimental traumatic brain injury. However, 
      therapeutic use of estrogens in this and other regards remains controversial. 
      Therefore, analysis of estrogen-like compounds without potential problems similar 
      to estrogens seems warranted. (+/-) Z-Bisdehydrodoisynolic acid (Z-BDDA) is a 
      seco-steroid that has potent estrogenic as well as antioxidant activities in 
      vitro and in vivo. We evaluated the therapeutic potential of Z-BDDA 
      (300mug/0.1cc/100g body weight, sc) to promote the recovery of behavioral function 
      following lateral fluid percussion injury (FPI) to the brain in male rats. Two 
      hours subsequent to FPI, treatment with Z-BDDA began with a bolus subcutaneous 
      (sc) injection followed by booster treatments given 24 and 48h later. Behavioral 
      testing was initiated on the second day after FPI and results of Z-BDDA 
      treatments were compared to treatment with vehicle only and to sham FPI surgery. 
      Z-BDDA effectively enhanced recovery of coordinated limb movement assessed by 
      locomotor placing performance across the duration of the study. Z-BDDA treated 
      animals also performed better on a spatial memory task in the Morris water maze, 
      showing improved learning curves across days of testing. Vestibulomotor function, 
      measured by beam walk performance, appeared to improve in Z-BDDA treated animals, 
      however these results did not reach statistical significance (p>0.05). Following 
      cessation of the behavioral testing, all animals underwent assessments of gross 
      neuroanatomical pathology. Cortical lesion size and cell death analysis with 
      Fluoro-jade B failed to reveal Z-BDDA enhanced neuroprotection. These findings 
      support our hypothesis that Z-BDDA can facilitate behavioral recovery following 
      FPI in adult male rats although the mechanism(s) of these effects remain to be 
      determined.
CI  - Copyright (c) 2010 Elsevier B.V. All rights reserved.
FAU - Neese, Steven L
AU  - Neese SL
AD  - Brain and Cognitive Sciences Program, Department of Psychology, Southern Illinois 
      University, Carbondale, IL 62901-6502, USA.
FAU - Clough, Rich W
AU  - Clough RW
FAU - Banz, William J
AU  - Banz WJ
FAU - Smith, Douglas C
AU  - Smith DC
LA  - eng
PT  - Journal Article
DEP - 20100924
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Estrogens)
RN  - 0 (Phenanthrenes)
RN  - 0 (Secosteroids)
RN  - 0 (bisdehydrodoisynolic acid)
SB  - IM
MH  - Animals
MH  - Brain Injuries/*drug therapy/metabolism/physiopathology
MH  - Disease Models, Animal
MH  - Estrogens/*agonists/physiology
MH  - Male
MH  - Phenanthrenes/*pharmacology/therapeutic use
MH  - Rats
MH  - Rats, Long-Evans
MH  - Recovery of Function/*drug effects/physiology
MH  - Secosteroids/*pharmacology/therapeutic use
EDAT- 2010/09/28 06:00
MHDA- 2011/09/29 06:00
CRDT- 2010/09/28 06:00
PHST- 2010/02/22 00:00 [received]
PHST- 2010/08/24 00:00 [revised]
PHST- 2010/09/15 00:00 [accepted]
PHST- 2010/09/28 06:00 [entrez]
PHST- 2010/09/28 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - S0006-8993(10)02086-X [pii]
AID - 10.1016/j.brainres.2010.09.055 [doi]
PST - ppublish
SO  - Brain Res. 2010 Nov 29;1362:93-101. doi: 10.1016/j.brainres.2010.09.055. Epub 
      2010 Sep 24.