PMID- 20872251
OWN - NLM
STAT- MEDLINE
DCOM- 20110916
LR  - 20211020
IS  - 1875-8312 (Electronic)
IS  - 1569-5794 (Linking)
VI  - 27
IP  - 4
DP  - 2011 Apr
TI  - Midregional pro-atrial natriuretic peptide: a novel marker of myocardial fibrosis 
      in patients with hypertrophic cardiomyopathy.
PG  - 547-56
LID - 10.1007/s10554-010-9704-2 [doi]
AB  - We aimed to determine the diagnostic performance of biomarkers in predicting 
      myocardial fibrosis assessed by late gadolinium enhancement (LGE) cardiovascular 
      magnetic resonance imaging (CMR) in patients with hypertrophic cardiomyopathy 
      (HCM). LGE CMR was performed in 40 consecutive patients with HCM. Left and right 
      ventricular parameters, as well as the extent of LGE were determined and 
      correlated to the plasma levels of midregional pro-atrial natriuretic peptide 
      (MR-proANP), midregional pro-adrenomedullin (MR-proADM), carboxy-terminal 
      pro-endothelin-1 (CT-proET-1), carboxy-terminal pro-vasopressin (CT-proAVP), 
      matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 
      (TIMP-1) and interleukin-8 (IL-8). Myocardial fibrosis was assumed positive, if 
      CMR indicated LGE. LGE was present in 26 of 40 patients with HCM (65%) with 
      variable extent (mean: 14%, range: 1.3-42%). The extent of LGE was positively 
      associated with MR-proANP (r = 0.4; P = 0.01). No correlations were found between 
      LGE and MR-proADM (r = 0.1; P = 0.5), CT-proET-1 (r = 0.07; P = 0.66), CT-proAVP 
      (r = 0.16; P = 0.3), MMP-9 (r = 0.01; P = 0.9), TIMP-1 (r = 0.02; P = 0.85), and 
      IL-8 (r = 0.02; P = 0.89). After adjustment for confounding factors, MR-proANP 
      was the only independent predictor associated with the presence of LGE (P = 
      0.007) in multivariate analysis. The area under the ROC curve (AUC) indicated 
      good predictive performance (AUC = 0.882) of MR-proANP with respect to LGE. The 
      odds ratio was 1.268 (95% confidence interval 1.066-1.508). The sensitivity of 
      MR-proANP at a cut-off value of 207 pmol/L was 69%, the specificity 94%, the 
      positive predictive value 90% and the negative predictive value 80%. The results 
      imply that MR-proANP serves as a novel marker of myocardial fibrosis assessed by 
      LGE CMR in patients with HCM.
FAU - Elmas, Elif
AU  - Elmas E
AD  - 1st Department of Medicine, University Medical Centre Mannheim, Medical Faculty 
      Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, 
      Germany.
FAU - Doesch, Christina
AU  - Doesch C
FAU - Fluechter, Stephan
AU  - Fluechter S
FAU - Freundt, Miriam
AU  - Freundt M
FAU - Weiss, Christel
AU  - Weiss C
FAU - Lang, Siegfried
AU  - Lang S
FAU - Kalsch, Thorsten
AU  - Kalsch T
FAU - Haghi, Dariush
AU  - Haghi D
FAU - Papassotiriou, Jana
AU  - Papassotiriou J
FAU - Kunde, Jan
AU  - Kunde J
FAU - Schoenberg, Stefan O
AU  - Schoenberg SO
FAU - Borggrefe, Martin
AU  - Borggrefe M
FAU - Papavassiliu, Theano
AU  - Papavassiliu T
LA  - eng
PT  - Journal Article
DEP - 20100926
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
RN  - 0 (Biomarkers)
RN  - 0 (CXCL8 protein, human)
RN  - 0 (Contrast Media)
RN  - 0 (Endothelin-1)
RN  - 0 (Glycopeptides)
RN  - 0 (Interleukin-8)
RN  - 0 (Protein Precursors)
RN  - 0 (Tissue Inhibitor of Metalloproteinase-1)
RN  - 0 (copeptins)
RN  - 0 (proadrenomedullin)
RN  - 0 (proendothelin 1)
RN  - 148498-78-6 (Adrenomedullin)
RN  - 85637-73-6 (Atrial Natriuretic Factor)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adrenomedullin/blood
MH  - Adult
MH  - Aged
MH  - Atrial Natriuretic Factor/*blood
MH  - Biomarkers/blood
MH  - Cardiomyopathy, Hypertrophic/*blood/pathology/physiopathology
MH  - Contrast Media
MH  - Endothelin-1/blood
MH  - Female
MH  - Fibrosis
MH  - Gadolinium DTPA
MH  - Germany
MH  - Glycopeptides/blood
MH  - Humans
MH  - Interleukin-8/blood
MH  - Logistic Models
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Matrix Metalloproteinase 9/blood
MH  - Middle Aged
MH  - Myocardium/*chemistry/pathology
MH  - Odds Ratio
MH  - Predictive Value of Tests
MH  - Protein Precursors/blood
MH  - ROC Curve
MH  - Stroke Volume
MH  - Tissue Inhibitor of Metalloproteinase-1/blood
MH  - Ventricular Function, Left
EDAT- 2010/09/28 06:00
MHDA- 2011/09/17 06:00
CRDT- 2010/09/28 06:00
PHST- 2010/05/16 00:00 [received]
PHST- 2010/09/10 00:00 [accepted]
PHST- 2010/09/28 06:00 [entrez]
PHST- 2010/09/28 06:00 [pubmed]
PHST- 2011/09/17 06:00 [medline]
AID - 10.1007/s10554-010-9704-2 [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2011 Apr;27(4):547-56. doi: 10.1007/s10554-010-9704-2. 
      Epub 2010 Sep 26.