PMID- 20872675
OWN - NLM
STAT- MEDLINE
DCOM- 20110131
LR  - 20161018
IS  - 1552-8618 (Electronic)
IS  - 0730-7268 (Linking)
VI  - 29
IP  - 10
DP  - 2010 Oct
TI  - Complex contaminant exposure in cetaceans: a comparative E-Screen analysis of 
      bottlenose dolphin blubber and mixtures of four persistent organic pollutants.
PG  - 2143-53
LID - 10.1002/etc.279 [doi]
AB  - Cetaceans are federally protected species that are prone to accumulate complex 
      mixtures of persistent organic pollutants (POPs), which individually may exert 
      estrogenic or antiestrogenic effects. In the present study it was assessed 
      whether contaminant mixtures harbored by cetaceans are estrogenic or 
      antiestrogenic using a comparative approach. Interactions of antiestrogenic and 
      estrogenic compounds were first investigated with the E-Screen assay using a 
      mixture of four POPs (dichlorodiphenyldichloroethylene [4,4'-DDE], 
      trans-nonachlor, and polychlorinated biphenyls [PCBs] 138 180) prevalent in 
      cetacean blubber. Estrogenic/antiestrogenic activity was determined for the 
      individual compounds and their binary, tertiary, and quaternary combinations. 
      Significantly different responses were observed for the various POP mixtures, 
      including enhanced estrogenic and antiestrogenic effects and antagonistic 
      interactions. These results were then compared to the concentrations and 
      estrogenic/antiestrogenic activity of contaminant mixtures isolated directly from 
      the blubber of 15 bottlenose dolphins (Tursiops truncatus) collected from five 
      U.S. Atlantic and Gulf of Mexico locations. The lowest observed effect 
      concentrations (LOECs) determined for 4,4'-DDE (20 micromol/L), PCB 138 (20 micromol/L), 
      PCB 180 (21 micromol/L), and trans-nonachlor (3 micromol/L) in the E-Screen were greater 
      than estimated dolphin blood concentrations. Although estimated blood 
      concentrations were below the LOECs, significant estrogenic activity was detected 
      in diluted dolphin blubber from Cape May, NJ and Bermuda. Positive correlations 
      between blubber estrogenicity and select POP concentrations (SigmaDDTs, SigmaPBDEs, SigmaHCB, 
      Sigmaestrogenic PCBs, Sigmaestrogenic POPs) were also observed. Collectively, these 
      results suggest that select bottlenose dolphin populations may be exposed to 
      contaminants that act in concert to exert estrogenic effects at biologically 
      relevant concentrations. These observations do not necessarily provide direct 
      evidence of endocrine disruption; however, they may indicate an environmental 
      source of xenoestrogenic exposure warranting future research.
CI  - Environ. Toxicol. Chem. 2010;29:2143-2153. (c) 2010 SETAC.
FAU - Yordy, Jennifer E
AU  - Yordy JE
AD  - Marine Biomedicine and Environmental Sciences Center, Medical University of South 
      Carolina, Charleston, South Carolina 29412, USA.
FAU - Mollenhauer, Meagan A M
AU  - Mollenhauer MA
FAU - Wilson, Rachel M
AU  - Wilson RM
FAU - Wells, Randall S
AU  - Wells RS
FAU - Hohn, Aleta
AU  - Hohn A
FAU - Sweeney, Jay
AU  - Sweeney J
FAU - Schwacke, Lori H
AU  - Schwacke LH
FAU - Rowles, Teri K
AU  - Rowles TK
FAU - Kucklick, John R
AU  - Kucklick JR
FAU - Peden-Adams, Margie M
AU  - Peden-Adams MM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Environ Toxicol Chem
JT  - Environmental toxicology and chemistry
JID - 8308958
RN  - 0 (Water Pollutants, Chemical)
SB  - IM
MH  - Adipose Tissue/*metabolism
MH  - Animals
MH  - Bottle-Nosed Dolphin
MH  - Cell Line, Tumor
MH  - Humans
MH  - Water Pollutants, Chemical/*toxicity
EDAT- 2010/09/28 06:00
MHDA- 2011/02/01 06:00
CRDT- 2010/09/28 06:00
PHST- 2010/09/28 06:00 [entrez]
PHST- 2010/09/28 06:00 [pubmed]
PHST- 2011/02/01 06:00 [medline]
AID - 10.1002/etc.279 [doi]
PST - ppublish
SO  - Environ Toxicol Chem. 2010 Oct;29(10):2143-53. doi: 10.1002/etc.279.