PMID- 20873543
OWN - NLM
STAT- MEDLINE
DCOM- 20110714
LR  - 20100929
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 24
IP  - 14
DP  - 2010 Jul
TI  - [Expression and significance of signal transducer and activator of transcription 
      3 and c-myc in laryngeal squamous cell carcinoma].
PG  - 648-51
AB  - OBJECTIVE: To investigate the expression and clinical significance of signal 
      transducer and activator of transcription 3(STAT3) and its target gene c-myc in 
      laryngeal squamous cell carcinoma (LSCC), and the relationship between the two 
      genes. METHOD: Formalin-fixed and paraffin-embedded tissues, which came from 56 
      cases of LSCC and 30 samples of normal mucosas from 30 patients with total or 
      subtotal laryngectomy over 2.0 cm away from tumor margin, were detected for the 
      expression of STATS, c-myc by in situ hybridization and SP immunohistochemistry. 
      Micro-image analysis system was used to determine the optical density, and the 
      result was analyzed statistically. RESULT: There is overexpression of STAT3, 
      c-myc mRNA and protein in LSCC. The expression of STAT3 and c-myc mRNA in LSCC 
      was associated with clinical stage, differentiation grade and lymph nodal 
      metastases (P < 0.05 or 0.01). The expression of STAT3 and c-myc protein in LSCC 
      was associated with clinical stage and lymph nodal metastases (P < 0.05 or 0.01). 
      There was a positive correlation between the expression of STAT3 and c-myc genes. 
      mRNA and protein, The correlation coefficient (r) was 0.6224 (P < 0.01) for the 
      mRNA expression and 0.7012 (P < 0.01 )for the protein expression. CONCLUSION: The 
      expression of STAT3 and c-myc may play an important role in the tumorigenesis, 
      metastases and poor prognosis of LSCC. There was a positive correlation between 
      the overexpression of STAT3 and c-myc genes in LSCC.
FAU - Liu, Tingyan
AU  - Liu T
AD  - Department of Otolaryngology-Head and Neck Surgery, Affiliated Hospital of 
      Hangzhou Normal University, Hangzhou, 310015, China. lty631230@163.com
FAU - Peng, Huaguang
AU  - Peng H
FAU - Wu, Zhenghu
AU  - Wu Z
FAU - Cui, Caixia
AU  - Cui C
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (Proto-Oncogene Proteins c-myc)
RN  - 0 (STAT3 Transcription Factor)
RN  - 0 (STAT3 protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Proto-Oncogene Proteins c-myc/*metabolism
MH  - STAT3 Transcription Factor/*metabolism
EDAT- 2010/09/30 06:00
MHDA- 2011/07/16 06:00
CRDT- 2010/09/30 06:00
PHST- 2010/09/30 06:00 [entrez]
PHST- 2010/09/30 06:00 [pubmed]
PHST- 2011/07/16 06:00 [medline]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2010 Jul;24(14):648-51.