PMID- 20875797
OWN - NLM
STAT- MEDLINE
DCOM- 20101201
LR  - 20191210
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 401
IP  - 4
DP  - 2010 Oct 29
TI  - TRIM39 and RNF39 are associated with Behcet's disease independently of HLA-B *51 
      and -A *26.
PG  - 533-7
LID - 10.1016/j.bbrc.2010.09.088 [doi]
AB  - Behcet's disease (BD) is a chronic inflammatory autoimmune disease and strongly 
      associated with human leukocyte antigen (HLA)-B *51 and -A *26. We examined whether 
      other genetic factors may exist in HLA region by 135 single nucleotide 
      polymorphisms (SNPs) in 384 pairs of Japanese BD patients and controls. Multiple 
      logistic regression analysis identified two novel susceptibility SNPs: rs9261365 
      near a ring finger protein (RNF) 39 and rs2074474 on exon 9 of tripartite 
      motif-containing (TRIM) 39 independently of HLA-B *51 and -A *26 alleles. Our 
      findings suggest that RNF39 and TRIM39 are involved in the etiology of BD.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Kurata, Riho
AU  - Kurata R
AD  - Department of Molecular Life Science, Tokai University School of Medicine, 
      Isehara, Kanagawa 259-1143, Japan.
FAU - Nakaoka, Hirofumi
AU  - Nakaoka H
FAU - Tajima, Atsushi
AU  - Tajima A
FAU - Hosomichi, Kazuyoshi
AU  - Hosomichi K
FAU - Shiina, Takashi
AU  - Shiina T
FAU - Meguro, Akira
AU  - Meguro A
FAU - Mizuki, Nobuhisa
AU  - Mizuki N
FAU - Ohono, Shigeaki
AU  - Ohono S
FAU - Inoue, Ituro
AU  - Inoue I
FAU - Inoko, Hidetoshi
AU  - Inoko H
LA  - eng
PT  - Journal Article
DEP - 20100927
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Carrier Proteins)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-A*26 antigen)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B51 Antigen)
RN  - 0 (Immediate-Early Proteins)
RN  - 0 (RNF39 protein, human)
RN  - EC 2.3.2.27 (TRIM39 protein, human)
RN  - EC 2.3.2.27 (Ubiquitin-Protein Ligases)
SB  - IM
MH  - Behcet Syndrome/*genetics
MH  - Carrier Proteins/*genetics
MH  - Genetic Predisposition to Disease
MH  - HLA-A Antigens/genetics
MH  - HLA-B Antigens/genetics
MH  - HLA-B51 Antigen
MH  - Haplotypes
MH  - Humans
MH  - Immediate-Early Proteins/*genetics
MH  - Japan
MH  - Polymorphism, Single Nucleotide
MH  - Ubiquitin-Protein Ligases
EDAT- 2010/09/30 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/09/30 06:00
PHST- 2010/09/14 00:00 [received]
PHST- 2010/09/22 00:00 [accepted]
PHST- 2010/09/30 06:00 [entrez]
PHST- 2010/09/30 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S0006-291X(10)01798-5 [pii]
AID - 10.1016/j.bbrc.2010.09.088 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2010 Oct 29;401(4):533-7. doi: 
      10.1016/j.bbrc.2010.09.088. Epub 2010 Sep 27.