PMID- 20875842
OWN - NLM
STAT- MEDLINE
DCOM- 20111031
LR  - 20240322
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 171
IP  - 3
DP  - 2010 Dec 15
TI  - Electrophysiological and structural alterations in striatum associated with 
      behavioral sensitization to (+/-)3,4-methylenedioxymethamphetamine (Ecstasy) in 
      rats: role of drug context.
PG  - 794-811
LID - 10.1016/j.neuroscience.2010.09.041 [doi]
AB  - We examined whether repeated exposure to the increasingly abused amphetamine 
      (AMPH) derivative 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) results in 
      long-lasting neurobehavioral changes, and further, the ability of contextual cues 
      to modulate these changes. We focused on dorsal striatum, a brain region 
      implicated in the formation of persistent drug-related habits. Rats were 
      transported to a novel recording chamber and treated with once-daily injections 
      (s.c.) of (+/-)-MDMA (5.0 mg/kg) or saline for 5 days, followed by a challenge 
      injection 14 days later either in the same (Experiment 1) or different context 
      (Experiment 2). Chronically implanted micro-wire bundles were used to record from 
      populations of striatal neurons on days 1, 5, and challenge. Twenty-four hours 
      after the last injection, brains were removed and processed using a modified 
      Golgi method to assess changes in neuronal morphology. A sensitized locomotor 
      response was observed following MDMA challenge in 11 of 12 rats in Experiment 1 
      (same context), whereas only 58% of rats (7 of 12) displayed sensitization in 
      Experiment 2 (different context). Furthermore, several alterations in striatal 
      electrophysiology were apparent on challenge day, but only in rats that displayed 
      sensitization. Conversely, structural changes in striatal medium spiny neurons, 
      such as increases in spine density, were observed in MDMA-treated rats regardless 
      of whether they displayed behavioral sensitization. Thus, it appears that 
      reorganization of synaptic connectivity in dorsal striatum may contribute to 
      long-lasting drug-induced behavioral alterations, but that these behavioral 
      alterations are subject to modification depending on individual differences and 
      the context surrounding drug administration.
CI  - Copyright (c) 2010 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Ball, K T
AU  - Ball KT
AD  - Department of Psychology, Bloomsburg University of Pennsylvania, 400 East Second 
      Street, Bloomsburg, PA 17815-1303, USA.
FAU - Wellman, C L
AU  - Wellman CL
FAU - Miller, B R
AU  - Miller BR
FAU - Rebec, G V
AU  - Rebec GV
LA  - eng
GR  - R01 DA012964/DA/NIDA NIH HHS/United States
GR  - DA 020209/DA/NIDA NIH HHS/United States
GR  - DA 12964/DA/NIDA NIH HHS/United States
GR  - DA 02451/DA/NIDA NIH HHS/United States
GR  - R01 DA002451-25/DA/NIDA NIH HHS/United States
GR  - F31 DA020209/DA/NIDA NIH HHS/United States
GR  - R01 DA002451/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100925
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Adrenergic Uptake Inhibitors)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adrenergic Uptake Inhibitors/toxicity
MH  - Animals
MH  - Behavior, Animal/*drug effects/physiology
MH  - Cell Shape/drug effects/physiology
MH  - Electrophysiology/methods
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*toxicity
MH  - Neostriatum/*drug effects/*pathology/physiopathology
MH  - Neurons/*drug effects/*pathology/physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Silver Staining/methods
PMC - PMC2987517
MID - NIHMS242024
EDAT- 2010/09/30 06:00
MHDA- 2011/11/01 06:00
PMCR- 2011/12/15
CRDT- 2010/09/30 06:00
PHST- 2010/07/01 00:00 [received]
PHST- 2010/09/02 00:00 [revised]
PHST- 2010/09/22 00:00 [accepted]
PHST- 2010/09/30 06:00 [entrez]
PHST- 2010/09/30 06:00 [pubmed]
PHST- 2011/11/01 06:00 [medline]
PHST- 2011/12/15 00:00 [pmc-release]
AID - S0306-4522(10)01289-3 [pii]
AID - 10.1016/j.neuroscience.2010.09.041 [doi]
PST - ppublish
SO  - Neuroscience. 2010 Dec 15;171(3):794-811. doi: 
      10.1016/j.neuroscience.2010.09.041. Epub 2010 Sep 25.