PMID- 20878395
OWN - NLM
STAT- MEDLINE
DCOM- 20110204
LR  - 20211020
IS  - 1432-1106 (Electronic)
IS  - 0014-4819 (Print)
IS  - 0014-4819 (Linking)
VI  - 207
IP  - 1-2
DP  - 2010 Nov
TI  - Self-specific processing in the default network: a single-pulse TMS study.
PG  - 27-38
LID - 10.1007/s00221-010-2425-x [doi]
AB  - In examining neural processing specific to the self, primarily by contrasting 
      self-related stimuli with non-self-related stimuli (i.e., self vs. other), 
      neuroimaging studies have activated a consistent set of regions, including medial 
      prefrontal cortex (MPFC), precuneus, and right and left inferior parietal cortex. 
      However, criticism has arisen that this network may not be specific to 
      self-related processing, but instead reflects a more general aspect of cortical 
      processing. For example, it is almost identical to the active network of the 
      resting state, the "default" mode, when the subject is free to think about 
      anything at all. We tested the self-specificity of this network by using 
      transcranial magnetic stimulation (TMS) to briefly disrupt local cortical 
      processing while subjects rated adjectives as like or unlike themselves or their 
      best friend. Healthy volunteers show a self-reference effect (SRE) in this task, 
      in which performance with self-related items is superior to that with 
      other-related items. As individual adjectives appeared on a monitor, single-pulse 
      TMS was applied at five different times relative to stimulus onset (SOA: stimulus 
      onset asynchrony) ranging from 0 to 480 ms. In 18 subjects, TMS to left parietal 
      cortex suppressed the SRE from 160 to 480 ms. SRE suppression occurred at later 
      SOA with TMS to the right parietal cortex. In contrast, no effects were seen with 
      TMS to MPFC. Together with our previous work, these results provide evidence for 
      a self-specific processing system in which midline and lateral inferior parietal 
      cortices, as elements of the default network, play a role in ongoing 
      self-awareness.
FAU - Lou, Hans C
AU  - Lou HC
AD  - Division of Brain Stimulation and Therapeutic Modulation, New York State 
      Psychiatric Institute, New York, NY, USA. hl@ipm.hosp.dk
FAU - Luber, Bruce
AU  - Luber B
FAU - Stanford, Arielle
AU  - Stanford A
FAU - Lisanby, Sarah H
AU  - Lisanby SH
LA  - eng
GR  - K23 MH076976/MH/NIMH NIH HHS/United States
GR  - K23 MH076976-01A1/MH/NIMH NIH HHS/United States
GR  - L30 MH072461/MH/NIMH NIH HHS/United States
GR  - L30 MH072461-01/MH/NIMH NIH HHS/United States
PT  - Journal Article
DEP - 20100929
PL  - Germany
TA  - Exp Brain Res
JT  - Experimental brain research
JID - 0043312
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Attention/physiology
MH  - Brain/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Nerve Net/*physiology
MH  - Personality/physiology
MH  - Photic Stimulation
MH  - Psychomotor Performance/physiology
MH  - Reaction Time/physiology
MH  - *Self Concept
MH  - Transcranial Magnetic Stimulation
PMC - PMC3008414
MID - NIHMS243844
EDAT- 2010/09/30 06:00
MHDA- 2011/02/05 06:00
PMCR- 2010/12/22
CRDT- 2010/09/30 06:00
PHST- 2010/04/02 00:00 [received]
PHST- 2010/09/09 00:00 [accepted]
PHST- 2010/09/30 06:00 [entrez]
PHST- 2010/09/30 06:00 [pubmed]
PHST- 2011/02/05 06:00 [medline]
PHST- 2010/12/22 00:00 [pmc-release]
AID - 10.1007/s00221-010-2425-x [doi]
PST - ppublish
SO  - Exp Brain Res. 2010 Nov;207(1-2):27-38. doi: 10.1007/s00221-010-2425-x. Epub 2010 
      Sep 29.