PMID- 20880110
OWN - NLM
STAT- MEDLINE
DCOM- 20110103
LR  - 20101027
IS  - 1365-2141 (Electronic)
IS  - 0007-1048 (Linking)
VI  - 151
IP  - 4
DP  - 2010 Nov
TI  - Novel interactions between UFH and TFPI in children.
PG  - 376-80
LID - 10.1111/j.1365-2141.2010.08373.x [doi]
AB  - The impact of age upon therapeutic response to unfractionated heparin (UFH) in 
      children is proposed to reflect quantitative and potentially qualitative 
      differences in coagulation proteins across childhood. This study explores the 
      UFH-dependent tissue factor pathway inhibitor (TFPI) release in children compared 
      to previously published data in adults. Children <16 years of age undergoing 
      cardiac angiography formed the population for this prospective cohort study. TFPI 
      release was measured prior to (baseline) and at 15, 30, 45 and 120 min post-UFH 
      dose. This study demonstrated that, whilst the immediate release of TFPI post-UFH 
      was similar in children compared to adults, TFPI release in children remained 
      increased and consistent for a significantly longer period post-UFH 
      administration compared to adults. Plasma TFPI levels in children did not 
      demonstrate an UFH concentration -dependent reduction, as has been previously 
      reported in adults. The prolonged TFPI-mediated anticoagulant levels observed in 
      children administered UFH may contribute to the increased rate of major bleeding 
      reported in children compared to adults. Furthermore, we postulate that this 
      sustained UFH-dependent increase in TFPI levels in children may influence the 
      binding of UFH to competitive plasma proteins, such as those involved in the 
      immunological response to UFH associated with heparin-induced thrombocytopenia.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Newall, Fiona
AU  - Newall F
AD  - Department of Paediatrics, The University of Melbourne, Royal Children's 
      Hospital, Parkville, Victoria, Australia. fiona.newall@rch.org.au
FAU - Johnston, Linda
AU  - Johnston L
FAU - Summerhayes, Robyn
AU  - Summerhayes R
FAU - Lane, Geoff
AU  - Lane G
FAU - Cranswick, Noel
AU  - Cranswick N
FAU - Monagle, Paul
AU  - Monagle P
FAU - Ignjatovic, Vera
AU  - Ignjatovic V
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100929
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
RN  - 0 (Anticoagulants)
RN  - 0 (Lipoproteins)
RN  - 0 (Protamines)
RN  - 0 (lipoprotein-associated coagulation inhibitor)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Adolescent
MH  - Aging/blood
MH  - Anticoagulants/administration & dosage/*pharmacology
MH  - Child
MH  - Child, Preschool
MH  - Coronary Angiography
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Heparin/administration & dosage/*pharmacology
MH  - Humans
MH  - Infant
MH  - Lipoproteins/*blood
MH  - Male
MH  - Prospective Studies
MH  - Protamines/blood
EDAT- 2010/10/01 06:00
MHDA- 2011/01/05 06:00
CRDT- 2010/10/01 06:00
PHST- 2010/10/01 06:00 [entrez]
PHST- 2010/10/01 06:00 [pubmed]
PHST- 2011/01/05 06:00 [medline]
AID - 10.1111/j.1365-2141.2010.08373.x [doi]
PST - ppublish
SO  - Br J Haematol. 2010 Nov;151(4):376-80. doi: 10.1111/j.1365-2141.2010.08373.x. 
      Epub 2010 Sep 29.