PMID- 20881473
OWN - NLM
STAT- MEDLINE
DCOM- 20110325
LR  - 20240320
IS  - 1473-5571 (Electronic)
IS  - 0269-9370 (Print)
IS  - 0269-9370 (Linking)
VI  - 24
IP  - 16
DP  - 2010 Oct 23
TI  - The Regai Dzive Shiri project: results of a randomized trial of an HIV prevention 
      intervention for youth.
PG  - 2541-52
LID - 10.1097/QAD.0b013e32833e77c9 [doi]
AB  - BACKGROUND: HIV prevention among young people in southern Africa is a public 
      health priority. There is little rigorous evidence of the effectiveness of 
      different intervention approaches. We describe findings of a cluster randomized 
      trial of a community-based, multicomponent HIV, and reproductive health 
      intervention aimed at changing social norms for adolescents in rural Zimbabwe. 
      METHODS: Thirty rural communities were randomized to early or deferred 
      implementation of the intervention in 2003. Impact was assessed in a 
      representative survey of 18-22-year-olds after 4 years. Participants 
      self-completed a questionnaire and gave a dried blood spot sample for HIV and 
      herpes simplex virus-2 (HSV-2) antibody testing. Young women had a urinary 
      pregnancy test. Analyses were by intention-to-treat and were adjusted for 
      clustering. FINDINGS: Four thousand six hundred and eighty-four, 18-22-year-olds 
      participated in the survey (97.1% of eligible candidates, 55.5% women). Just over 
      40% had been exposed to at least 10 intervention sessions. There were modest 
      improvements in knowledge and attitudes among young men and women in intervention 
      communities, but no impact on self-reported sexual behavior. There was no impact 
      of the intervention on prevalence of HIV or HSV-2 or current pregnancy. Women in 
      intervention communities were less likely to report ever having been pregnant. 
      INTERPRETATION: Despite an impact on knowledge, some attitudes, and reported 
      pregnancy, there was no impact of this intervention on HIV or HSV-2 prevalence, 
      further evidence that behavioral interventions alone are unlikely to be 
      sufficient to reverse the HIV epidemic. The challenge remains to find effective 
      HIV prevention approaches for young people in the face of continued and 
      unacceptably high HIV incidence, particularly among young women.
FAU - Cowan, Frances M
AU  - Cowan FM
AD  - Centre for Sexual Health and HIV Research, University College London Medical 
      School, London, UK. francesmcowan@yahoo.co.uk
FAU - Pascoe, Sophie J S
AU  - Pascoe SJ
FAU - Langhaug, Lisa F
AU  - Langhaug LF
FAU - Mavhu, Webster
AU  - Mavhu W
FAU - Chidiya, Samson
AU  - Chidiya S
FAU - Jaffar, Shabbar
AU  - Jaffar S
FAU - Mbizvo, Michael T
AU  - Mbizvo MT
FAU - Stephenson, Judith M
AU  - Stephenson JM
FAU - Johnson, Anne M
AU  - Johnson AM
FAU - Power, Robert M
AU  - Power RM
FAU - Woelk, Godfrey
AU  - Woelk G
FAU - Hayes, Richard J
AU  - Hayes RJ
CN  - Regai Dzive Shiri trial team
LA  - eng
GR  - G0700837/MRC_/Medical Research Council/United Kingdom
GR  - R01 MH066570/MH/NIMH NIH HHS/United States
GR  - R01 MH-66570/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - AIDS
JT  - AIDS (London, England)
JID - 8710219
SB  - IM
MH  - Adolescent
MH  - Cluster Analysis
MH  - Female
MH  - HIV Infections/epidemiology/*prevention & control
MH  - *HIV-1
MH  - Health Education/*methods
MH  - Health Knowledge, Attitudes, Practice
MH  - Health Promotion
MH  - Herpes Simplex/epidemiology/*prevention & control
MH  - Humans
MH  - Male
MH  - Pregnancy
MH  - Rural Health
MH  - Rural Population
MH  - Sex Education/methods
MH  - Young Adult
MH  - Zimbabwe/epidemiology
PMC - PMC3058934
MID - NIHMS237455
EDAT- 2010/10/01 06:00
MHDA- 2011/03/26 06:00
PMCR- 2011/10/23
CRDT- 2010/10/01 06:00
PHST- 2010/10/01 06:00 [entrez]
PHST- 2010/10/01 06:00 [pubmed]
PHST- 2011/03/26 06:00 [medline]
PHST- 2011/10/23 00:00 [pmc-release]
AID - 10.1097/QAD.0b013e32833e77c9 [doi]
PST - ppublish
SO  - AIDS. 2010 Oct 23;24(16):2541-52. doi: 10.1097/QAD.0b013e32833e77c9.