PMID- 20881490
OWN - NLM
STAT- MEDLINE
DCOM- 20140513
LR  - 20181202
IS  - 1531-7013 (Electronic)
IS  - 1087-2418 (Linking)
VI  - 15
IP  - 6
DP  - 2010 Dec
TI  - Infections due to human herpesvirus 6 in solid organ transplant recipients.
PG  - 671-5
LID - 10.1097/MOT.0b013e3283404325 [doi]
AB  - PURPOSE OF REVIEW: This article summarizes the current state of the epidemiology, 
      diagnosis, and management of human herpesvirus 6 (HHV-6) infection after solid 
      organ transplantation. RECENT FINDINGS: HHV-6 reactivates commonly during the 
      early weeks after solid organ transplantation. However, disease due to HHV-6 is 
      uncommon and is manifested as a febrile illness associated with rash and 
      tissue-invasive manifestations such as encephalitis, hepatitis, pneumonitis, and 
      gastrointestinal disease. HHV-6 has also been indirectly associated with other 
      opportunistic infections such as cytomegalovirus and fungal infections. Molecular 
      tests such as PCR assays are preferred methods for the diagnosis of HHV-6 
      infection. Recent guideline from the American Society of Transplantation 
      Infectious Disease Community of Practice does not recommend specific antiviral 
      prophylaxis or preemptive therapy for HHV-6 infection. For established disease, 
      intravenous ganciclovir and foscarnet are considered first-line agents. SUMMARY: 
      Infection due to HHV-6 is a common after transplantation, but clinical disease is 
      rare. Nonetheless, this infection has been indirectly associated with poor 
      allograft and patient survival after transplantation. No specific prevention 
      strategy is recommended, but treatment of established HHV-6 disease consists of 
      antiviral therapy with intravenous ganciclovir and/or foscarnet, and reduction in 
      immunosuppression.
FAU - Razonable, Raymund R
AU  - Razonable RR
AD  - aDivision of Infectious Diseases, USA bWilliam J. von Liebig Transplant Center, 
      College of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Organ Transplant
JT  - Current opinion in organ transplantation
JID - 9717388
RN  - 0 (Antiviral Agents)
RN  - 0 (Immunosuppressive Agents)
SB  - IM
MH  - Antiviral Agents/therapeutic use
MH  - Herpesviridae Infections/diagnosis/drug therapy/*epidemiology/etiology
MH  - *Herpesvirus 6, Human
MH  - Humans
MH  - Immunosuppressive Agents/therapeutic use
MH  - Opportunistic Infections/diagnosis/drug therapy/*epidemiology/etiology
MH  - *Organ Transplantation/adverse effects
MH  - Risk Factors
EDAT- 2010/10/01 06:00
MHDA- 2014/05/14 06:00
CRDT- 2010/10/01 06:00
PHST- 2010/10/01 06:00 [entrez]
PHST- 2010/10/01 06:00 [pubmed]
PHST- 2014/05/14 06:00 [medline]
AID - 10.1097/MOT.0b013e3283404325 [doi]
PST - ppublish
SO  - Curr Opin Organ Transplant. 2010 Dec;15(6):671-5. doi: 
      10.1097/MOT.0b013e3283404325.