PMID- 20882065
OWN - NLM
STAT- MEDLINE
DCOM- 20110801
LR  - 20220318
IS  - 1995-8218 (Electronic)
IS  - 1673-7067 (Print)
IS  - 1995-8218 (Linking)
VI  - 26
IP  - 5
DP  - 2010 Oct
TI  - Effects of electrical stimulation of dorsal raphe nucleus on neuronal response 
      properties of barrel cortex layer IV neurons following long-term sensory 
      deprivation.
PG  - 388-94
AB  - OBJECTIVE: To evaluate the effect of electrical stimulation of dorsal raphe 
      nucleus (DRN) on response properties of layer IV barrel cortex neurons following 
      long-term sensory deprivation. METHODS: Male Wistar rats were divided into 
      sensory-deprived (SD) and control (unplucked) groups. In SD group, all vibrissae 
      except the D2 vibrissa were plucked on postnatal day one, and kept plucked for a 
      period of 60 d. After that, whisker regrowth was allowed for 8-10 d. The D2 
      principal whisker (PW) and the D1 adjacent whisker (AW) were either deflected 
      singly or both deflected in a serial order that the AW was deflected 20 ms before 
      PW deflection for assessing lateral inhibition, and neuronal responses were 
      recorded from layer IV of the D2 barrel cortex. DRN was electrically stimulated 
      at inter-stimulus intervals (ISIs) ranging from 0 to 800 ms before whisker 
      deflection. RESULTS: PW-evoked responses increased in the SD group with DRN 
      electrical stimulation at ISIs of 50 ms and 100 ms, whereas AW-evoked responses 
      increased at ISI of 800 ms in both groups. Whisker plucking before DRN 
      stimulation could enhance the responsiveness of barrel cortex neurons to PW 
      deflection and decrease the responsiveness to AW deflection. DRN electrical 
      stimulation significantly reduced this difference only in PW-evoked responses 
      between groups. Besides, no DRN stimulation-related changes in response latency 
      were observed following PW or AW deflection in either group. Moreover, condition 
      test (CT) ratio increased in SD rats, while DRN stimulation did not affect the CT 
      ratio in either group. There was no obvious change in 5-HT(2A) receptor protein 
      density in barrel cortex between SD and control groups. CONCLUSION: These results 
      suggest that DRN electrical stimulation can modulate information processing in 
      the SD barrel cortex.
FAU - Sheikhkanloui-Milan, Hamid
AU  - Sheikhkanloui-Milan H
AD  - Neuroscience Research Center and Department of Physiology, Kerman University of 
      Medical Sciences, Kerman 76198-13159, Iran.
FAU - Sheibani, Vahid
AU  - Sheibani V
FAU - Afarinesh, Mohammadreza
AU  - Afarinesh M
FAU - Esmaeili-Mahani, Saeed
AU  - Esmaeili-Mahani S
FAU - Shamsizadeh, Ali
AU  - Shamsizadeh A
FAU - Sepehri, Golamreza
AU  - Sepehri G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Singapore
TA  - Neurosci Bull
JT  - Neuroscience bulletin
JID - 101256850
RN  - 0 (Receptor, Serotonin, 5-HT2A)
SB  - IM
MH  - Animals
MH  - Denervation/methods
MH  - Electric Stimulation/methods
MH  - Male
MH  - Neuronal Plasticity/*physiology
MH  - Neurons/*physiology
MH  - Raphe Nuclei/pathology/*physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Reaction Time/physiology
MH  - Receptor, Serotonin, 5-HT2A/physiology
MH  - Sensory Deprivation/*physiology
MH  - Somatosensory Cortex/pathology/*physiology
MH  - Time Factors
PMC - PMC5552602
EDAT- 2010/10/01 06:00
MHDA- 2011/08/02 06:00
PMCR- 2011/10/01
CRDT- 2010/10/01 06:00
PHST- 2010/10/01 06:00 [entrez]
PHST- 2010/10/01 06:00 [pubmed]
PHST- 2011/08/02 06:00 [medline]
PHST- 2011/10/01 00:00 [pmc-release]
AID - 412 [pii]
AID - 10.1007/s12264-010-0412-7 [doi]
PST - ppublish
SO  - Neurosci Bull. 2010 Oct;26(5):388-94. doi: 10.1007/s12264-010-0412-7.