PMID- 20884011
OWN - NLM
STAT- MEDLINE
DCOM- 20110418
LR  - 20111117
IS  - 1878-5883 (Electronic)
IS  - 0022-510X (Linking)
VI  - 300
IP  - 1-2
DP  - 2011 Jan 15
TI  - Spinal cord involvement in multiple sclerosis: a correlative MRI and 
      high-resolution HLA-DRB1 genotyping study.
PG  - 114-9
LID - 10.1016/j.jns.2010.09.006 [doi]
AB  - BACKGROUND: There have been few magnetic resonance imaging (MRI) studies of the 
      spinal cord in large multiple sclerosis (MS) patient cohorts and little is known 
      about correlations between cord lesions and human leukocyte antigen (HLA) 
      alleles. OBJECTIVE: To investigate the spectrum of MRI changes in the spinal cord 
      in MS and associations with the HLA-DRB1 genotype. METHODS: Two hundred and fifty 
      two consecutive MS patients from the Perth Demyelinating Diseases Database had 
      MRI of the spinal cord and brain and high-resolution HLA-DRB1 genotyping. The 
      numbers, locations, shape and segmental extent of cord lesions were analysed and 
      were correlated with carriage of individual HLA-DRB1 alleles and diplotypes. 
      RESULTS: Focal cord lesions were present in 82.9% of cases, with numbers being 
      maximal in the cervical cord and increasing with disease duration. Focal lesions 
      were usually round or oval in shape but in 35% of cases subpial wedge-shaped 
      lesions were present. Diffuse cord involvement was present in 10% of cases and 
      correlated with carriage of HLA-DRB1*1501 and with higher disability. Carriage of 
      the minor allele HLA-DRB1*0701 was significantly associated with numbers of 
      wedge-shaped lesions and lesions in the cervical cord, while HLA-DRB1*1104 and 
      DRB1*0103 were significantly associated respectively with higher and lower 
      numbers of thoracic cord lesions. HLA-DRB1*1501 and the HLA-DRB1*11 sub-alleles 
      DRB1*1101 and DRB1*1104 were significantly associated with the segmental length 
      of cord lesions. CONCLUSIONS: Our study is the first to investigate the frequency 
      of subpial wedge-shaped lesions in the cord in vivo and has provided preliminary 
      evidence that HLA-DRB1 alleles may play a role in determining the severity and 
      extent of spinal cord involvement in MS.
CI  - Copyright (c) 2010 Elsevier B.V. All rights reserved.
FAU - Qiu, Wei
AU  - Qiu W
AD  - Multiple Sclerosis Center, Department of Neurology, the Third Affiliated Hospital 
      of Sun Yat-Sen University, Guangzhou, China.
FAU - Raven, Sonja
AU  - Raven S
FAU - James, Ian
AU  - James I
FAU - Luo, Yuebei
AU  - Luo Y
FAU - Wu, Jingshan
AU  - Wu J
FAU - Castley, Alison
AU  - Castley A
FAU - Christiansen, Frank T
AU  - Christiansen FT
FAU - Carroll, William M
AU  - Carroll WM
FAU - Mastaglia, Frank L
AU  - Mastaglia FL
FAU - Kermode, Allan G
AU  - Kermode AG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Female
MH  - Genotype
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/diagnosis/*genetics/*pathology
MH  - Spinal Cord/*pathology
EDAT- 2010/10/05 06:00
MHDA- 2011/04/19 06:00
CRDT- 2010/10/02 06:00
PHST- 2010/06/02 00:00 [received]
PHST- 2010/08/08 00:00 [revised]
PHST- 2010/09/07 00:00 [accepted]
PHST- 2010/10/02 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2011/04/19 06:00 [medline]
AID - S0022-510X(10)00442-9 [pii]
AID - 10.1016/j.jns.2010.09.006 [doi]
PST - ppublish
SO  - J Neurol Sci. 2011 Jan 15;300(1-2):114-9. doi: 10.1016/j.jns.2010.09.006.