PMID- 20884860
OWN - NLM
STAT- MEDLINE
DCOM- 20110128
LR  - 20211203
IS  - 1092-874X (Electronic)
IS  - 1091-5818 (Linking)
VI  - 29
IP  - 5
DP  - 2010 Sep-Oct
TI  - Effect of astragaloside IV on the general and peripartum reproductive toxicity in 
      Sprague-Dawley rats.
PG  - 505-16
LID - 10.1177/1091581810376840 [doi]
AB  - Fertility and early embryonic developmental toxicity in rats were evaluated by 
      intravenously administering astragaloside IV (AS-IV) daily at 0.25, 0.5, and 1.0 
      mg/kg for 4 weeks before mating, throughout the mating period, and continuing to 
      day 6 of gestation period in females. Perinatal toxicity in rats was evaluated on 
      gestational days (GD) 15 to 21 and lactational days LD (LD) 1 to 21. 
      Astragaloside IV had no maternal toxicity at 0.25 to 1.0 mg/kg in rats. Although 
      it has an inhibitory effect on female fertility in F0/F1 rats, AS-IV was devoid 
      of early embryonic developmental toxicity in F0/F1 rats and in the survival 
      parameters of F1 postnatal rats. Maternal AS-IV exposure at the dose of 1.0 mg/kg 
      per d resulted in a significant delay in time for fur development, eye opening, 
      and cliff parry reflex of pups compared to control group (P < .05), whereas it 
      did not affect the memory and learning of F1 pups.
FAU - Xuying, Wan
AU  - Xuying W
AD  - Department of Toxicology, Second Military Medical University, Shanghai 200433, PR 
      China. toxiboy2001@yahoo.com.cn.
FAU - Jiangbo, Zhu
AU  - Jiangbo Z
FAU - Yuping, Zhu
AU  - Yuping Z
FAU - Xili, Ma
AU  - Xili M
FAU - Yiwen, Zheng
AU  - Yiwen Z
FAU - Tianbao, Zhang
AU  - Tianbao Z
FAU - Weidong, Zhang
AU  - Weidong Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Int J Toxicol
JT  - International journal of toxicology
JID - 9708436
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Saponins)
RN  - 0 (Triterpenes)
RN  - 3A592W8XKE (astragaloside A)
RN  - 922OP8YUPF (Huang Qi)
SB  - IM
MH  - Animals
MH  - Astragalus Plant/chemistry/toxicity
MH  - Astragalus propinquus
MH  - Dose-Response Relationship, Drug
MH  - Drugs, Chinese Herbal/chemistry/toxicity
MH  - Embryonic Development/drug effects
MH  - Female
MH  - Infertility, Female/chemically induced
MH  - Infertility, Male/chemically induced
MH  - Lactation
MH  - Male
MH  - Maternal Exposure/adverse effects
MH  - Paternal Exposure/adverse effects
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/chemically induced/mortality
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reproduction/*drug effects
MH  - Saponins/administration & dosage/*toxicity
MH  - Toxicity Tests
MH  - Triterpenes/administration & dosage/*toxicity
EDAT- 2010/10/05 06:00
MHDA- 2011/02/01 06:00
CRDT- 2010/10/02 06:00
PHST- 2010/10/02 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2011/02/01 06:00 [medline]
AID - 29/5/505 [pii]
AID - 10.1177/1091581810376840 [doi]
PST - ppublish
SO  - Int J Toxicol. 2010 Sep-Oct;29(5):505-16. doi: 10.1177/1091581810376840.