PMID- 20885164
OWN - NLM
STAT- MEDLINE
DCOM- 20110111
LR  - 20221207
IS  - 1526-0976 (Electronic)
IS  - 1089-2591 (Linking)
VI  - 14
IP  - 4
DP  - 2010 Oct
TI  - Off-label high-risk HPV DNA testing of vaginal ASC-US and LSIL cytologic 
      abnormalities at Parkland hospital.
PG  - 352-5
LID - 10.1097/LGT.0b013e3181f0b69d [doi]
AB  - OBJECTIVE: To investigate the frequency and outcome of high-risk human 
      papillomavirus (HPV) DNA testing of atypical squamous cell of unknown 
      significance (ASC-US) and low-grade squamous intraepithelial lesion (LSIL) 
      vaginal ThinPrep Pap tests (TPPTs). METHODS: Atypical squamous cell of unknown 
      significance and LSIL vaginal TPPTs (from women without a cervix) from 2005 to 
      2008 were identified retrospectively. The frequency of HPV testing in response to 
      these cytologic abnormalities and results of testing were determined and compared 
      with cervical TPPTs. The frequency and results of subsequent vaginal biopsies 
      were reviewed. RESULTS: Of the ASC-US vaginal TPPTs, 76.5% (270/353) underwent 
      HPV testing, with 31.9% (86/270) positive. Atypical squamous cell of unknown 
      significance cervical TPPTs underwent HPV testing less often (69.5%, 
      7,155/10,297) but were more commonly HPV-positive (49.7%, 3,558/7,155). 
      Similarly, the majority of LSIL vaginal TPPTs (59.2%, 202/341) underwent HPV 
      testing, with 66% (133/202) testing positive. This compares with only 11.0% 
      (1,092/9,947) of cervical LSIL TPPTs undergoing HPV testing, with 73.2% 
      (799/1,092) positive. The increased rates of HPV test performance and lower rates 
      of HPV positivity in vaginal ASC-US and LSIL TPPTs compared with similarly 
      abnormal cervical TPPTs were statistically significant (p <.05) by chi analysis. 
      Histologic evaluation was more common after HPV-positive ASC-US or LSIL vaginal 
      TPPTs compared with HPV-negative results. Most high-grade vaginal neoplasias were 
      diagnosed subsequent to a positive HPV result. CONCLUSIONS: Human papillomavirus 
      testing of ASC-US and LSIL vaginal TPPTs is common; lower rates of HPV positivity 
      were found in vaginal versus cervical ASC-US and LSIL TPPTs. The majority of 
      high-grade vaginal neoplasias were diagnosed subsequent to positive HPV testing. 
      Evidence-based guidelines for the use of HPV testing for the management of 
      vaginal cytologic abnormalities are needed.
FAU - Chappell, Catherine A
AU  - Chappell CA
AD  - Parkland Health and Hospital System, Dallas, TX, USA.
FAU - West, Ann Marie
AU  - West AM
FAU - Kabbani, Wareef
AU  - Kabbani W
FAU - Werner, Claudia L
AU  - Werner CL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Low Genit Tract Dis
JT  - Journal of lower genital tract disease
JID - 9704963
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - DNA, Viral/genetics/*isolation & purification
MH  - Female
MH  - Hospitals
MH  - Humans
MH  - Mass Screening/*methods
MH  - Middle Aged
MH  - Molecular Diagnostic Techniques/statistics & numerical data
MH  - Papillomaviridae/classification/genetics/*isolation & purification
MH  - Papillomavirus Infections/*diagnosis/virology
MH  - United States
MH  - Uterine Cervical Neoplasms/*diagnosis/pathology/virology
MH  - Virology/*methods
MH  - Uterine Cervical Dysplasia/*diagnosis/pathology/virology
EDAT- 2010/10/05 06:00
MHDA- 2011/01/12 06:00
CRDT- 2010/10/02 06:00
PHST- 2010/10/02 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2011/01/12 06:00 [medline]
AID - 00128360-201010000-00013 [pii]
AID - 10.1097/LGT.0b013e3181f0b69d [doi]
PST - ppublish
SO  - J Low Genit Tract Dis. 2010 Oct;14(4):352-5. doi: 10.1097/LGT.0b013e3181f0b69d.