PMID- 20886249
OWN - NLM
STAT- MEDLINE
DCOM- 20110406
LR  - 20211020
IS  - 1434-9949 (Electronic)
IS  - 0770-3198 (Linking)
VI  - 30
IP  - 1
DP  - 2011 Jan
TI  - Tumor necrosis factor-alpha (TNF-alpha)-blockade-induced hepatic sarcoidosis in 
      psoriatic arthritis (PsA): case report and review of the literature.
PG  - 133-7
LID - 10.1007/s10067-010-1577-1 [doi]
AB  - To study the cytokine profile in a 52 year old woman with psoriasis, PsA, and HCV 
      who developed hepatic sarcoidosis following Etanercept therapy for 7 months. 11 
      PsA patients on TNF blockers mean disease duration 158.4 (SD 114.5), mean 
      treatment duration 72.1 (SD 42.14) months, 8/11 PsA were on Etanercept and 5 
      healthy controls were studied. TNF-alpha, sTNF RI/RII, IFN-alpha/beta/gamma, IL-1 alpha, IL-15, 
      IL-6, VEGF, s IL-1 R, sIL-6 R, IL-12, IL-23, IL-17, Adiponectin, Leptin and EGF 
      were assessed. All PsA and controls tested negative for Quantiferon TB Gold, 
      hepatitis B/C, HIV, ACE level, chest x-ray, liver function test (LFTs). Serologic 
      biomarkers of the subject in comparison to the controls indicate that sTNF RI 
      value was significantly higher; and IL-1 alpha level has a high outlier compared 
      to the 11 PsA patients on TNF blockers. The clinical course, histologic findings, 
      increased levels of s TNF R I and IL-1 alpha in the subject as compared to the other 
      PsA on TNF blockade and controls, suggest that most likely Etanercept induced 
      inflammatory cytokine imbalance was responsible for inducing hepatic sarcoidosis.
FAU - Cuchacovich, Raquel
AU  - Cuchacovich R
AD  - Medicine Department, Louisiana State University Health Sciences Center, New 
      Orleans, LA, USA. rcucha@hotmail.com
FAU - Hagan, Joseph
AU  - Hagan J
FAU - Khan, Tahir
AU  - Khan T
FAU - Richert, Arthur
AU  - Richert A
FAU - Espinoza, Luis R
AU  - Espinoza LR
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20101001
PL  - Germany
TA  - Clin Rheumatol
JT  - Clinical rheumatology
JID - 8211469
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Arthritis, Psoriatic/complications/*immunology
MH  - Female
MH  - Granuloma/complications/immunology
MH  - Hepacivirus/genetics
MH  - Hepatitis C/complications/immunology
MH  - Humans
MH  - Liver/*immunology
MH  - Liver Diseases/complications/*immunology
MH  - Middle Aged
MH  - Psoriasis/complications/immunology
MH  - Sarcoidosis/complications/*immunology
MH  - Treatment Outcome
MH  - Tumor Necrosis Factor-alpha/*antagonists & inhibitors
MH  - Viral Load
EDAT- 2010/10/05 06:00
MHDA- 2011/04/07 06:00
CRDT- 2010/10/02 06:00
PHST- 2010/07/18 00:00 [received]
PHST- 2010/09/13 00:00 [accepted]
PHST- 2010/10/02 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2011/04/07 06:00 [medline]
AID - 10.1007/s10067-010-1577-1 [doi]
PST - ppublish
SO  - Clin Rheumatol. 2011 Jan;30(1):133-7. doi: 10.1007/s10067-010-1577-1. Epub 2010 
      Oct 1.