PMID- 20888104
OWN - NLM
STAT- MEDLINE
DCOM- 20101109
LR  - 20220408
IS  - 1523-6838 (Electronic)
IS  - 0272-6386 (Linking)
VI  - 56
IP  - 5
DP  - 2010 Nov
TI  - Association of urinary biomarkers with disease severity in patients with 
      autosomal dominant polycystic kidney disease: a cross-sectional analysis.
PG  - 883-95
LID - 10.1053/j.ajkd.2010.06.023 [doi]
AB  - BACKGROUND: Disease monitoring of autosomal dominant polycystic kidney disease 
      (ADPKD) will become more important with potential upcoming therapeutic 
      interventions. Because serum creatinine level is considered of limited use and 
      measurement of effective renal blood flow (ERBF) and total renal volume are time 
      consuming and expensive, there is a need for other biomarkers. We aimed to 
      investigate which urinary markers have increased levels in patients with ADPKD; 
      whether these urinary markers are associated with measured glomerular filtration 
      rate (mGFR), ERBF, and total renal volume; and whether these associations are 
      independent of albuminuria (urine albumin excretion [UAE]). STUDY DESIGN: 
      Diagnostic test study. SETTING & PARTICIPANTS: 102 patients with ADPKD (Ravine 
      criteria) and 102 age- and sex-matched healthy controls. INDEX TEST: 24-hour 
      urinary excretion of glomerular (immunoglobulin G), proximal tubular (kidney 
      injury molecule 1 [KIM-1], N-acetyl-beta-d-glucosaminidase, neutrophil 
      gelatinase-associated lipocalin [NGAL], and beta(2)-microglobulin), and distal 
      tubular (heart-type fatty acid binding protein [H-FABP]) damage markers and 
      inflammatory markers (monocyte chemotactic protein 1 [MCP-1] and macrophage 
      migration inhibitory factor). REFERENCE TEST: Disease severity assessed using 
      measures of kidney function (mGFR and ERBF, measured using clearance of 
      iothalamate labeled with iodine 125 and hippuran labeled with iodine 131 during 
      continuous infusion, respectively) and structure (total renal volume, measured 
      using magnetic resonance imaging). OTHER MEASUREMENTS: 24-hour UAE. RESULTS: In 
      102 patients with ADPKD (aged 40 +/- 11 years; 58% men), levels of all measured 
      urinary biomarkers were increased compared with healthy controls. Excretion of 
      immunoglobulin G and albumin relatively were most increased. ERBF and mGFR values 
      were associated with urinary excretion of beta(2)-microglobulin, NGAL, and H-FABP 
      independent of UAE, whereas total renal volume was associated with KIM-1, NGAL, 
      and MCP-1 independent of UAE. LIMITATIONS: Cross-sectional, single center. 
      CONCLUSIONS: Levels of markers for multiple parts of the nephron are increased in 
      patients with ADPKD. In addition to measurement of UAE, measurement of urinary 
      beta(2)-microglobulin, KIM-1, H-FABP, MCP-1, and especially NGAL could be of value 
      for determination of disease severity in patients with ADPKD.
CI  - Copyright (c) 2010 National Kidney Foundation, Inc. Published by Elsevier Inc. All 
      rights reserved.
FAU - Meijer, Esther
AU  - Meijer E
AD  - Division of Nephrology, Department of Internal Medicine, University Medical 
      Center Groningen, University of Groningen, Groningen, the Netherlands.
FAU - Boertien, Wendy E
AU  - Boertien WE
FAU - Nauta, Ferdau L
AU  - Nauta FL
FAU - Bakker, Stephan J L
AU  - Bakker SJ
FAU - van Oeveren, Wim
AU  - van Oeveren W
FAU - Rook, Mieneke
AU  - Rook M
FAU - van der Jagt, Eric J
AU  - van der Jagt EJ
FAU - van Goor, Harry
AU  - van Goor H
FAU - Peters, Dorien J M
AU  - Peters DJ
FAU - Navis, Gerjan
AU  - Navis G
FAU - de Jong, Paul E
AU  - de Jong PE
FAU - Gansevoort, Ron T
AU  - Gansevoort RT
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Am J Kidney Dis
JT  - American journal of kidney diseases : the official journal of the National Kidney 
      Foundation
JID - 8110075
RN  - 0 (Acute-Phase Proteins)
RN  - 0 (Biomarkers)
RN  - 0 (FABP3 protein, human)
RN  - 0 (Fatty Acid Binding Protein 3)
RN  - 0 (Fatty Acid-Binding Proteins)
RN  - 0 (Immunoglobulin G)
RN  - 0 (LCN2 protein, human)
RN  - 0 (Lipocalin-2)
RN  - 0 (Lipocalins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (beta 2-Microglobulin)
RN  - EC 3.2.1.52 (Acetylglucosaminidase)
SB  - IM
MH  - Acetylglucosaminidase/*urine
MH  - Acute-Phase Proteins
MH  - Adult
MH  - Biomarkers/*urine
MH  - Cross-Sectional Studies
MH  - Disease Progression
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Fatty Acid Binding Protein 3
MH  - Fatty Acid-Binding Proteins/*urine
MH  - Female
MH  - Follow-Up Studies
MH  - Glomerular Filtration Rate
MH  - Humans
MH  - Immunoglobulin G/*urine
MH  - Lipocalin-2
MH  - Lipocalins
MH  - Male
MH  - Netherlands/epidemiology
MH  - Polycystic Kidney, Autosomal Dominant/diagnosis/epidemiology/*urine
MH  - Prevalence
MH  - Prognosis
MH  - Proto-Oncogene Proteins
MH  - *Severity of Illness Index
MH  - beta 2-Microglobulin/*urine
EDAT- 2010/10/05 06:00
MHDA- 2010/11/10 06:00
CRDT- 2010/10/05 06:00
PHST- 2010/03/27 00:00 [received]
PHST- 2010/06/22 00:00 [accepted]
PHST- 2010/10/05 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2010/11/10 06:00 [medline]
AID - S0272-6386(10)01149-2 [pii]
AID - 10.1053/j.ajkd.2010.06.023 [doi]
PST - ppublish
SO  - Am J Kidney Dis. 2010 Nov;56(5):883-95. doi: 10.1053/j.ajkd.2010.06.023.