PMID- 20888550
OWN - NLM
STAT- MEDLINE
DCOM- 20101217
LR  - 20220317
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 150
IP  - 6
DP  - 2010 Dec
TI  - Comparison of retinal nerve fiber layer thickness in normal eyes using 
      time-domain and spectral-domain optical coherence tomography.
PG  - 807-14
LID - 10.1016/j.ajo.2010.06.024 [doi]
AB  - PURPOSE: To compare retinal nerve fiber layer (RNFL) thickness measurements 
      between 3 different spectral-domain optical coherence tomography (SD-OCT) 
      instruments (Spectralis; Heidelberg Engineering; Cirrus; Carl Zeiss Meditec; 
      RTVue; Optovue, Inc) and one time-domain OCT (Stratus; Carl Zeiss Meditec). 
      DESIGN: Prospective, cross-sectional study. METHODS: RNFL thickness was measured 
      on both eyes of 40 normal subjects using Stratus, Spectralis, RTVue, and Cirrus 
      OCT on the same day. Scans were repeated 2 to 8 weeks later in the same fashion. 
      Agreement with Stratus was evaluated for each SD-OCT and intervisit 
      reproducibility was assessed for all machines. RESULTS: Mean RNFL thickness 
      determined by each of the 3 SD-OCT instruments was highly correlated with Stratus 
      (r = 0.87-0.91). The mean RNFL thickness (mean +/- standard deviation) was 110.1 +/- 
      12.8 mum for Stratus, 106.6 +/- 12.8 mum for Spectralis, 98.7 +/- 10.9 mum for Cirrus, 
      and 112.8 +/- 13.2 mum for RTVue. The average differences between each SD-OCT and 
      Stratus for mean RNFL thickness were all statistically significant (P </= .001), as 
      were most quadrant measurements. All 4 instruments demonstrated excellent 
      intraclass correlation coefficient values for mean RNFL thickness (0.90-0.97). 
      However, intervisit variability was lowest for RTVue as evidenced by 
      reproducibility values, followed by Stratus, Cirrus, and Spectralis (6.59, 8.83, 
      8.89, and 11.72 mum, respectively). CONCLUSIONS: RNFL measurements taken with 
      Spectralis, RTVue, and Cirrus all have excellent correlation to Stratus, with 
      good reproducibility in normal eyes. Despite high correlations, RNFL values are 
      significantly different between instruments and should not be used 
      interchangeably.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Seibold, Leonard K
AU  - Seibold LK
AD  - Rocky Mountain Lions Eye Institute, Department of Ophthalmology, University of 
      Colorado at Denver, Aurora, Colorado 80045, USA.
FAU - Mandava, Naresh
AU  - Mandava N
FAU - Kahook, Malik Y
AU  - Kahook MY
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
MH  - Adult
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Nerve Fibers
MH  - Optic Disk/*anatomy & histology
MH  - Prospective Studies
MH  - Reference Values
MH  - Reproducibility of Results
MH  - Retinal Ganglion Cells/*cytology
MH  - Tomography, Optical Coherence/*instrumentation
MH  - Visual Acuity
MH  - Young Adult
EDAT- 2010/10/05 06:00
MHDA- 2010/12/18 06:00
CRDT- 2010/10/05 06:00
PHST- 2010/03/25 00:00 [received]
PHST- 2010/06/15 00:00 [revised]
PHST- 2010/06/15 00:00 [accepted]
PHST- 2010/10/05 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2010/12/18 06:00 [medline]
AID - S0002-9394(10)00450-2 [pii]
AID - 10.1016/j.ajo.2010.06.024 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2010 Dec;150(6):807-14. doi: 10.1016/j.ajo.2010.06.024.