PMID- 2089179
OWN - NLM
STAT- MEDLINE
DCOM- 19910528
LR  - 20191029
IS  - 0021-5120 (Print)
IS  - 0021-5120 (Linking)
VI  - 29
IP  - 5
DP  - 1990 Sep-Oct
TI  - Immunogenetical penetrance in patients with primary biliary cirrhosis.
PG  - 533-6
AB  - Two family cases of primary biliary cirrhosis (PBC) followed by the existence of 
      autoantibodies such as anti-mitochondrial antibody, anti-nuclear antibody and 
      anti-thyroid antibody are reported. Case O M has typical PBC, however, case H E 
      is complicated by asymptomatic polymyositis. Common haplotypes of human leukocyte 
      antigen (HLA) were observed as A24-Bw61 in the family members of case O M who had 
      autoantibodies. Only the mother of case H E had identical HLA haplotypes such as 
      A2, Aw31, Bw46, Bw61, DRw8, DRw52 and DQw1. From these results, it can be 
      suggested that immunogenetic penetrance might be associated with the occurrence 
      of familial PBC.
FAU - Shibasaki, T
AU  - Shibasaki T
AD  - Second Department of Internal Medicine, Jikei University School of Medicine, 
      Tokyo, Japan.
FAU - Shimada, T
AU  - Shimada T
FAU - Morita, T
AU  - Morita T
FAU - Sakai, O
AU  - Sakai O
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Jpn J Med
JT  - Japanese journal of medicine
JID - 0247713
RN  - 0 (Autoantibodies)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Autoantibodies/analysis/immunology
MH  - Autoimmune Diseases/complications/*genetics/immunology
MH  - Genetic Predisposition to Disease
MH  - HLA Antigens/genetics
MH  - Haplotypes
MH  - Humans
MH  - Liver Cirrhosis, Biliary/complications/*genetics/immunology
MH  - Liver Function Tests
MH  - Male
MH  - Middle Aged
MH  - Myositis/complications
RF  - 14
EDAT- 1990/09/01 00:00
MHDA- 1990/09/01 00:01
CRDT- 1990/09/01 00:00
PHST- 1990/09/01 00:00 [pubmed]
PHST- 1990/09/01 00:01 [medline]
PHST- 1990/09/01 00:00 [entrez]
AID - 10.2169/internalmedicine1962.29.533 [doi]
PST - ppublish
SO  - Jpn J Med. 1990 Sep-Oct;29(5):533-6. doi: 10.2169/internalmedicine1962.29.533.