PMID- 20919806
OWN - NLM
STAT- MEDLINE
DCOM- 20110913
LR  - 20220409
IS  - 1747-7174 (Electronic)
IS  - 1747-7166 (Print)
IS  - 1747-7166 (Linking)
VI  - 6
IP  - 2
DP  - 2011 Apr
TI  - Obesity is associated with impaired cardiac autonomic modulation in children.
PG  - 128-34
LID - 10.3109/17477166.2010.490265 [doi]
AB  - OBJECTIVE: To examine the cross-sectional association between measurements of 
      obesity and subclinical impairment of cardiac autonomic modulation (CAM) in a 
      population-based sample of children. METHODS: Data from 616 grade K-5 children 
      randomly selected from Central Pennsylvania were utilized. Obesity was defined 
      using the International Obesity Task Force (IOTF) age- and sex-specific cut-off 
      criteria and classified as normal weight, overweight, and obese. CAM was measured 
      by heart rate variability (HRV) analysis of beat-to-beat RR intervals, including 
      time domain measures i.e., the standard deviation of all RR intervals (SDNN), the 
      square root of the mean of the sum of squares of differences between adjacent RR 
      intervals (RMSSD), and mean heart rate (HR); and frequency domain measures i.e., 
      high frequency power (HF), low frequency power (LF), and LF/HF ratio. RESULTS: 
      The prevalence of obesity and overweight in children was 12.3%, and 16.5%, 
      respectively. Age, race, sex, and sleep disorder breathing (SDB) adjusted means 
      (standard error, SE) of SDNN were 98 (1.24), 90.2 (2.58), and 81.9 (3.03) 
      milliseconds (ms) in normal weight, overweight, and obese groups, respectively; 
      and that for (log) HF were 6.83 (0.04), 6.56 (0.08), and 6.35 (0.09) ms(2), 
      respectively. Comparing the magnitude of effects from body mass index (BMI), 
      weight, and height percentiles, and waist circumference on HRV indices revealed 
      that body weight was the strongest correlate of HRV indices. CONCLUSION: 
      Childhood obesity is significantly associated with lower HRV, indicative of 
      sympathetic overflow unopposed by parasympathetic modulation. These findings 
      support the need to target childhood-obesity before traditional "high risk age" 
      for cardiac events.
FAU - Rodriguez-Colon, Sol M
AU  - Rodriguez-Colon SM
AD  - Department of Public Health Sciences, Penn State University College of Medicine, 
      Hershey, PA 17033, USA.
FAU - Bixler, Edward O
AU  - Bixler EO
FAU - Li, Xian
AU  - Li X
FAU - Vgontzas, Alexandros N
AU  - Vgontzas AN
FAU - Liao, Duanping
AU  - Liao D
LA  - eng
GR  - M01 RR010732/RR/NCRR NIH HHS/United States
GR  - R21 HL087858/HL/NHLBI NIH HHS/United States
GR  - C06 RR016499/RR/NCRR NIH HHS/United States
GR  - C06RR016499/RR/NCRR NIH HHS/United States
GR  - R21HL087858-01/HL/NHLBI NIH HHS/United States
GR  - R01 HL63772/HL/NHLBI NIH HHS/United States
GR  - UL1 TR000127/TR/NCATS NIH HHS/United States
GR  - R01 HL063772/HL/NHLBI NIH HHS/United States
GR  - M01RR010732/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20101004
PL  - England
TA  - Int J Pediatr Obes
JT  - International journal of pediatric obesity : IJPO : an official journal of the 
      International Association for the Study of Obesity
JID - 101256330
SB  - IM
MH  - Autonomic Nervous System/*physiopathology
MH  - Body Mass Index
MH  - Cross-Sectional Studies
MH  - Electrocardiography
MH  - Female
MH  - Heart/*innervation
MH  - *Heart Rate
MH  - Humans
MH  - Male
MH  - Obesity/*physiopathology
PMC - PMC3647369
MID - NIHMS463585
COIS- Conflict of Interest statement: There is NO conflict of interest and NO off-label 
      or investigational use of drugs.
EDAT- 2010/10/06 06:00
MHDA- 2011/09/14 06:00
PMCR- 2013/05/08
CRDT- 2010/10/06 06:00
PHST- 2010/10/06 06:00 [entrez]
PHST- 2010/10/06 06:00 [pubmed]
PHST- 2011/09/14 06:00 [medline]
PHST- 2013/05/08 00:00 [pmc-release]
AID - 10.3109/17477166.2010.490265 [doi]
PST - ppublish
SO  - Int J Pediatr Obes. 2011 Apr;6(2):128-34. doi: 10.3109/17477166.2010.490265. Epub 
      2010 Oct 4.