PMID- 20920209
OWN - NLM
STAT- MEDLINE
DCOM- 20110201
LR  - 20211020
IS  - 1471-230X (Electronic)
IS  - 1471-230X (Linking)
VI  - 10
DP  - 2010 Sep 28
TI  - Bleeding from gastrointestinal angioectasias is not related to bleeding disorders 
      - a case control study.
PG  - 113
LID - 10.1186/1471-230X-10-113 [doi]
AB  - BACKGROUND: Angioectasias in the gastrointestinal tract can be found in up to 3% 
      of the population. They are typically asymptomatic but may sometimes result in 
      severe bleeding. The reasons for why some patients bleed from their angioectasias 
      are not fully understood but it has been reported that it may be explained by an 
      acquired von Willebrand syndrome (AVWS). This condition has similar laboratory 
      findings to congenital von Willebrand disease with selective loss of large von 
      Willebrand multimers. The aim of this study was to find out if AVWS or any other 
      bleeding disorder was more common in patients with bleeding from angioectasias 
      than in a control group. METHODS: We compared bleeding tests and coagulation 
      parameters, including von Willebrand multimers, from a group of 23 patients with 
      anemia caused by bleeding from angioectasias, with the results from a control 
      group lacking angioectasias. RESULTS: No significant differences between the two 
      groups were found in coagulation parameters, bleeding time or von Willebrand 
      multimer levels. CONCLUSION: These results do not support a need for routine 
      bleeding tests in cases of bleeding from angioectasias and do not show an overall 
      increased risk of AVWS among these patients.
FAU - Hoog, Charlotte M
AU  - Hoog CM
AD  - Department of Medicine, Karolinska Institutet, Stockholm Soder Hospital, 
      Stockholm, Sweden. charlotte.hoog@sodersjukhuset.se
FAU - Brostrom, Olle
AU  - Brostrom O
FAU - Lindahl, Tomas L
AU  - Lindahl TL
FAU - Hillarp, Andreas
AU  - Hillarp A
FAU - Larfars, Gerd
AU  - Larfars G
FAU - Sjoqvist, Urban
AU  - Sjoqvist U
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20100928
PL  - England
TA  - BMC Gastroenterol
JT  - BMC gastroenterology
JID - 100968547
RN  - 0 (Blood Coagulation Factors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Angiodysplasia/blood/*complications/diagnosis
MH  - Bleeding Time
MH  - Blood Coagulation Disorders/*diagnosis
MH  - Blood Coagulation Factors/*metabolism
MH  - Capsule Endoscopy/methods
MH  - Diagnosis, Differential
MH  - Female
MH  - Gastrointestinal Hemorrhage/blood/diagnosis/*etiology
MH  - Gastrointestinal Tract/*blood supply
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
PMC - PMC2955688
EDAT- 2010/10/06 06:00
MHDA- 2011/02/02 06:00
PMCR- 2010/09/28
CRDT- 2010/10/06 06:00
PHST- 2009/10/12 00:00 [received]
PHST- 2010/09/28 00:00 [accepted]
PHST- 2010/10/06 06:00 [entrez]
PHST- 2010/10/06 06:00 [pubmed]
PHST- 2011/02/02 06:00 [medline]
PHST- 2010/09/28 00:00 [pmc-release]
AID - 1471-230X-10-113 [pii]
AID - 10.1186/1471-230X-10-113 [doi]
PST - epublish
SO  - BMC Gastroenterol. 2010 Sep 28;10:113. doi: 10.1186/1471-230X-10-113.