PMID- 20920612
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20110228
IS  - 1873-0183 (Electronic)
IS  - 1568-9972 (Linking)
VI  - 10
IP  - 4
DP  - 2011 Feb
TI  - Catastrophic antiphospholipid syndrome in a community-acquired 
      methicillin-resistant Staphylococcus aureus infection: a review of pathogenesis 
      with a case for molecular mimicry.
PG  - 181-8
LID - 10.1016/j.autrev.2010.09.023 [doi]
AB  - Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) has 
      remarkable pathogenicity and can cause severe infections, such as necrotizing 
      pneumonia, necrotizing fasciitis, and sepsis. To our knowledge, no case of 
      CA-MRSA resulting in catastrophic antiphospholipid syndrome (CAPS) has been 
      reported. Furthermore, no specific pathogenic link between these two disorders 
      has been described. Staphylococcal sequence homologies and binding capabilities 
      to plasma protein beta2-glycoprotein I (beta2-GPI) may result in anti-beta2-GPI antibody 
      production. These antibodies represent the critical prothrombotic factor in 
      pathogenesis of antiphospholipid syndrome and CAPS. However, the development of 
      CAPS requires additional prothrombotic activities. In our case, sepsis and 
      CA-MRSA-induced leukocytolysis likely represent the activity required to 
      transform a hypercoagulable state into the life threatening, diffusely thrombotic 
      CAPS. The presence of anti-beta2GPI-antibodies and diffuse microvascular occlusion 
      are characteristic of CAPS. However, other life threatening syndromes cause 
      microvascular thrombi and multiorgan failure, and more studies are needed to 
      determine the frequency of antiphospholipid antibodies and clinical syndromes 
      consistent with CAPS in patients with staphylococcal infections.
CI  - Copyright (c) 2010 Elsevier B.V. All rights reserved.
FAU - Martin, Eric
AU  - Martin E
AD  - Department of Internal Medicine, Texas Tech University Health Sciences Center, 
      3601 4th Street, Lubbock, TX 79430, USA.
FAU - Winn, Richard
AU  - Winn R
FAU - Nugent, Kenneth
AU  - Nugent K
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20101013
PL  - Netherlands
TA  - Autoimmun Rev
JT  - Autoimmunity reviews
JID - 101128967
RN  - 0 (beta 2-Glycoprotein I)
SB  - IM
CIN - Autoimmun Rev. 2011 Feb;10(4):238. PMID: 20974295
MH  - Antiphospholipid Syndrome/diagnosis/*etiology/mortality/*physiopathology/therapy
MH  - Autoimmunity
MH  - Community-Acquired Infections/*complications/diagnosis
MH  - Humans
MH  - Methicillin-Resistant Staphylococcus aureus/*physiology
MH  - Molecular Mimicry/*immunology
MH  - Staphylococcal Infections/*complications
MH  - beta 2-Glycoprotein I/immunology
EDAT- 2010/10/06 06:00
MHDA- 2011/06/29 06:00
CRDT- 2010/10/06 06:00
PHST- 2010/09/05 00:00 [received]
PHST- 2010/09/25 00:00 [accepted]
PHST- 2010/10/06 06:00 [entrez]
PHST- 2010/10/06 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
AID - S1568-9972(10)00219-3 [pii]
AID - 10.1016/j.autrev.2010.09.023 [doi]
PST - ppublish
SO  - Autoimmun Rev. 2011 Feb;10(4):181-8. doi: 10.1016/j.autrev.2010.09.023. Epub 2010 
      Oct 13.