PMID- 20922407
OWN - NLM
STAT- MEDLINE
DCOM- 20110210
LR  - 20211020
IS  - 1432-2307 (Electronic)
IS  - 0945-6317 (Linking)
VI  - 458
IP  - 1
DP  - 2011 Jan
TI  - Glucagon expression in cystic pancreatic neuroendocrine neoplasms: an 
      immunohistochemical analysis.
PG  - 47-53
LID - 10.1007/s00428-010-0985-6 [doi]
AB  - Pancreatic neuroendocrine neoplasms (P-NENs) are usually solid and only rarely 
      cystic. Glucagon expression and the association with multiple endocrine neoplasia 
      type 1 (MEN1) seem to be common in cystic P-NENs. In this study, we analyzed 404 
      P-NENs to gain information about the relative frequency of grossly cystic P-NENs 
      and their association with glucagon production by the tumor cells. Three hundred 
      forty-six solitary P-NENs and 58 P-NENs (>1 cm in diameter) from 35 patients with 
      an MEN1 syndrome were studied. Immunostaining was performed for the four 
      pancreatic hormones; 5.5% (19/346) of the sporadic P-NENs showed unilocular or 
      multilocular cystic changes that were macroscopically detectable. Sixty-three 
      percent of the solitary cystic P-NENs (versus 7% of the solitary non-cystic 
      P-NENs) expressed predominantly glucagon. In MEN1-associated P-NENs, the relative 
      frequency of cystic tumors was 10.3%, and all of them expressed glucagon. None of 
      the glucagon-positive cystic P-NENs were associated with a glucagonoma syndrome. 
      Solitary non-MEN1-associated and MEN1-associated cystic P-NENs are predominantly 
      non-syndromic glucagon-expressing tumors. However, cystic insulinomas may also 
      occur. Cyst formation seems to be related to hormone production.
FAU - Konukiewitz, Bjorn
AU  - Konukiewitz B
AD  - Department of Pathology, University of Kiel, Kiel, Germany.
FAU - Enosawa, Tetsuji
AU  - Enosawa T
FAU - Kloppel, Gunter
AU  - Kloppel G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101005
PL  - Germany
TA  - Virchows Arch
JT  - Virchows Archiv : an international journal of pathology
JID - 9423843
RN  - 0 (Cadherins)
RN  - 0 (Pancreatic Hormones)
RN  - 0 (Platelet Endothelial Cell Adhesion Molecule-1)
RN  - 0 (beta Catenin)
RN  - 9007-92-5 (Glucagon)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cadherins/metabolism
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Glucagon/*metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia/epidemiology/*metabolism/pathology
MH  - Neuroendocrine Tumors/epidemiology/*metabolism/pathology
MH  - Pancreatic Hormones/metabolism
MH  - Pancreatic Neoplasms/epidemiology/*metabolism/pathology
MH  - Platelet Endothelial Cell Adhesion Molecule-1/metabolism
MH  - Prevalence
MH  - Retrospective Studies
MH  - Young Adult
MH  - beta Catenin/metabolism
EDAT- 2010/10/06 06:00
MHDA- 2011/02/11 06:00
CRDT- 2010/10/06 06:00
PHST- 2010/08/30 00:00 [received]
PHST- 2010/09/16 00:00 [accepted]
PHST- 2010/09/15 00:00 [revised]
PHST- 2010/10/06 06:00 [entrez]
PHST- 2010/10/06 06:00 [pubmed]
PHST- 2011/02/11 06:00 [medline]
AID - 10.1007/s00428-010-0985-6 [doi]
PST - ppublish
SO  - Virchows Arch. 2011 Jan;458(1):47-53. doi: 10.1007/s00428-010-0985-6. Epub 2010 
      Oct 5.