PMID- 20923479
OWN - NLM
STAT- MEDLINE
DCOM- 20110202
LR  - 20131121
IS  - 1753-0407 (Electronic)
IS  - 1753-0407 (Linking)
VI  - 2
IP  - 3
DP  - 2010 Sep
TI  - Gut hormones and the brain.
PG  - 138-45
LID - 10.1111/j.1753-0407.2009.00056.x [doi]
AB  - The dialogue between gut hormone, bile acids, and the brain plays an important 
      role in energy homeostasis and the onset of Type 2 diabetes mellitus (T2DM). The 
      present review focuses on: (i) bile acid metabolism and the role of bile acids in 
      the regulation of both glucose homeostasis and the control of 
      hypercholesterolemia; (ii) the role of gut hormones in energy homeostasis; and 
      (iii) translation of the pathophysiology of bile acids and gut hormones into 
      clinical practice. Although definitive mechanisms of action of gut hormones and 
      bile acids have not been elucidated completely, these concepts allow us to 
      understand several pharmacological interventions in the treatment of T2DM. 
      Results from further clinical studies with related therapies will help us 
      determine the role of these treatments in the management of energy homeostasis.
CI  - (c) 2010 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and 
      Blackwell Publishing Asia Pty Ltd.
FAU - Zhang, Yifei
AU  - Zhang Y
AD  - Shanghai Clinical Center for Endocrine and Metabolic Diseases and Division of 
      Endocrine and Metabolic Diseases of E-Institutes of Shanghai Universities, 
      Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 
      China.
FAU - Ning, Guang
AU  - Ning G
FAU - Handelsman, Yehuda
AU  - Handelsman Y
FAU - Bloomgarden, Zachary T
AU  - Bloomgarden ZT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Australia
TA  - J Diabetes
JT  - Journal of diabetes
JID - 101504326
RN  - 0 (Bile Acids and Salts)
RN  - 0 (Gastrointestinal Hormones)
RN  - 0 (Ghrelin)
RN  - 0 (Incretins)
RN  - 0 (Leptin)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Bile Acids and Salts/physiology
MH  - Brain/*physiology
MH  - Gastrointestinal Hormones/*physiology
MH  - Ghrelin/physiology
MH  - Glucose/metabolism
MH  - Homeostasis
MH  - Humans
MH  - Hypercholesterolemia/prevention & control
MH  - Incretins/physiology
MH  - Leptin/physiology
MH  - Receptors, Cytoplasmic and Nuclear/physiology
MH  - Satiety Response/*physiology
EDAT- 2010/10/07 06:00
MHDA- 2011/02/03 06:00
CRDT- 2010/10/07 06:00
PHST- 2010/10/07 06:00 [entrez]
PHST- 2010/10/07 06:00 [pubmed]
PHST- 2011/02/03 06:00 [medline]
AID - 10.1111/j.1753-0407.2009.00056.x [doi]
PST - ppublish
SO  - J Diabetes. 2010 Sep;2(3):138-45. doi: 10.1111/j.1753-0407.2009.00056.x.