PMID- 20923526
OWN - NLM
STAT- MEDLINE
DCOM- 20110202
LR  - 20230906
IS  - 1753-0407 (Electronic)
IS  - 1753-0407 (Linking)
VI  - 1
IP  - 4
DP  - 2009 Dec
TI  - Ethnic difference in patients with type 2 diabetes mellitus in inter-East Asian 
      populations: a systematic review and meta-analysis focusing on gene polymorphism.
PG  - 255-62
LID - 10.1111/j.1753-0407.2009.00040.x [doi]
AB  - BACKGROUND: We previously reported that the fasting serum insulin level was 
      significantly lower in Japanese patients than in Korean and Chinese patients, and 
      showed evidence that a difference in the dietary component would be one of the 
      most influential factors for the ethnic difference. However, it is well known 
      that type 2 diabetes mellitus (T2DM) results from the interaction between genetic 
      predispositions and environmental risk factors. Therefore, we investigated ethnic 
      differences by focusing on gene polymorphism, possibly related to T2DM in 
      Japanese, Korean, and Chinese subjects. METHODS: Data sources included MEDLINE 
      and EMBASE between January 2001 and October 2008. We conducted a search for 
      articles containing minor allele frequency (MAF) in the gene polymorphisms of 
      peroxisome proliferator-activated receptor-gamma (PPARG), inward-rectifying potassium 
      channel Kir6.2 (KCNJ11), Calpain 10 (CAPN10), and transcription factor 7-like 2 
      (TCF7L2). The pooled odds ratio was calculated by using a fixed-effects model 
      with the Mantel-Haenszel method after confirming statistical evidence of 
      homogeneity across the ethnicities using the Breslow-Day test. RESULTS: The 
      Breslow-Day test revealed that there were no statistically significant 
      differences between ethnicities in pooled odds ratios for the gene polymorphisms 
      in PPARG (P = 0.828), KCNJ11 (P = 0.194), CAPN10 (P = 0.090), and TCF7L2 (P = 
      0.376). Also, pooled odds ratios of each gene polymorphism in East Asians were 
      0.645 for PPARG (P = 0.000), 1.168 for KCNJ11 (P = 0.000), 0.967 for CAPN10 (P = 
      0.759), and 1.386 for TCF7L2 (P = 0.000). CONCLUSION: The results of this study 
      and our previous studies suggest that behavioral and environmental risk factors 
      have a more significant impact on ethnic difference in East Asian patients with 
      T2DM compared with genetic predispositions.
CI  - (c) 2009 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and 
      Blackwell Publishing Asia Pty Ltd.
FAU - Takeuchi, Masakazu
AU  - Takeuchi M
AD  - Pharmaceutical Information Science, Graduate School of Pharmaceutical Sciences, 
      Osaka University, Suita, Osaka, Japan. takema@gen-info.osaka-u.ac.jp
FAU - Okamoto, Kousuke
AU  - Okamoto K
FAU - Takagi, Tatsuya
AU  - Takagi T
FAU - Ishii, Hitoshi
AU  - Ishii H
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20090702
PL  - Australia
TA  - J Diabetes
JT  - Journal of diabetes
JID - 101504326
SB  - IM
MH  - Alleles
MH  - Asian People/*genetics
MH  - China
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Ethnicity/*genetics
MH  - Asia, Eastern
MH  - Gene Frequency
MH  - Humans
MH  - Japan
MH  - Korea
MH  - Odds Ratio
MH  - *Polymorphism, Genetic
MH  - Polymorphism, Single Nucleotide
MH  - Sample Size
EDAT- 2010/10/07 06:00
MHDA- 2011/02/03 06:00
CRDT- 2010/10/07 06:00
PHST- 2010/10/07 06:00 [entrez]
PHST- 2010/10/07 06:00 [pubmed]
PHST- 2011/02/03 06:00 [medline]
AID - 10.1111/j.1753-0407.2009.00040.x [doi]
PST - ppublish
SO  - J Diabetes. 2009 Dec;1(4):255-62. doi: 10.1111/j.1753-0407.2009.00040.x. Epub 
      2009 Jul 2.