PMID- 20923541 OWN - NLM STAT- MEDLINE DCOM- 20110121 LR - 20220129 IS - 1753-0407 (Electronic) IS - 1753-0407 (Linking) VI - 1 IP - 3 DP - 2009 Sep TI - Early life factors and type 2 diabetes in south India: Do the associations change with age? PG - 218-26 LID - 10.1111/j.1753-0407.2009.00036.x [doi] AB - BACKGROUND: Studies since the early 1990s have shown that birth size can be a predictor of the development of Type 2 diabetes mellitus (T2DM). In the present study, we evaluated changes in the strength of associations between T2DM and birth size and maternal weight with age. METHODS: In 1993-1994 (t(0)), 509 men and women (mean age 46 years) who had been born in Holdsworth Memorial Hospital were screened for diabetes, with increased diabetes risk identified in those who were shorter at birth and those born to heavier mothers. Ten years later (t(1)(0)), the screening was repeated in 266 subjects who were non-diabetic at t(0) (70% of survivors). RESULTS: At t(1)(0), 56 new cases of diabetes were found. The incidence of diabetes decreased with increasing birth length (odds ratio (OR) = 0.90, 95% confidence interval (CI) 0.84-0.97/cm birth length; P = 0.006) after adjustment for sex, age, socioeconomic status, family history, and current body mass index. Overall, there were no significant differences in OR for the association between birth length and diabetes at t(0) compared with t(1)(0), but limiting analysis to subjects with normal glucose tolerance at t(0) resulted in a stronger association at t(1)(0) (OR = 0.71, 95% CI 0.58-0.87) than at t(0) (OR = 0.95, 95% CI 0.86-1.05; P = 0.015 for the difference). There was a positive correlation between maternal weight and incident disease at t(0) (OR = 1.08, 95% CI 1.03-1.14; P = 0.001), but not at t(1)(0) (OR = 0.98/kg, 95% CI 0.92-1.05; P = 0.6; P = 0.02 for the difference). CONCLUSIONS: Short birth length remains a risk factor for diabetes. Changes in the effects of birth length and maternal weight on diabetes risk with age may indicate different causal pathways. These findings require replication in studies with more accurate dating of the onset of diabetes. CI - (c) 2009 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and Blackwell Publishing Asia Pty Ltd. FAU - Veena, Sargoor R AU - Veena SR AD - Holdsworth Memorial Hospital, Mysore, Karnataka, India. veenasr@gmail.com FAU - Wills, Andrew K AU - Wills AK FAU - Fisher, David J AU - Fisher DJ FAU - Stein, Claudia E AU - Stein CE FAU - Kumaran, Kalyanaraman AU - Kumaran K FAU - Krishnaveni, Ghattu V AU - Krishnaveni GV FAU - Kiran, Krishnarajasagara N AU - Kiran KN FAU - Coakley, Patsy J AU - Coakley PJ FAU - Fall, Caroline H D AU - Fall CH LA - eng GR - G0400519/MRC_/Medical Research Council/United Kingdom GR - U.1475.00.004.00005.01(74246)/MRC_/Medical Research Council/United Kingdom GR - 079877/WT_/Wellcome Trust/United Kingdom GR - MC_U147585821/MRC_/Medical Research Council/United Kingdom GR - MC_U147574246/MRC_/Medical Research Council/United Kingdom PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20090630 PL - Australia TA - J Diabetes JT - Journal of diabetes JID - 101504326 RN - 0 (Blood Glucose) SB - IM MH - Adult MH - Age Factors MH - Aging/*physiology MH - Algorithms MH - Birth Weight MH - Blood Glucose/metabolism MH - Body Height/physiology MH - Body Weight/physiology MH - Diabetes Mellitus, Type 2/diagnosis/*epidemiology/genetics MH - Female MH - Follow-Up Studies MH - Glucose Tolerance Test MH - Humans MH - India/epidemiology MH - Infant, Newborn MH - Male MH - Middle Aged MH - Pregnancy MH - Risk Factors MH - Social Class EDAT- 2010/10/07 06:00 MHDA- 2011/01/22 06:00 CRDT- 2010/10/07 06:00 PHST- 2010/10/07 06:00 [entrez] PHST- 2010/10/07 06:00 [pubmed] PHST- 2011/01/22 06:00 [medline] AID - 10.1111/j.1753-0407.2009.00036.x [doi] PST - ppublish SO - J Diabetes. 2009 Sep;1(3):218-26. doi: 10.1111/j.1753-0407.2009.00036.x. Epub 2009 Jun 30.