PMID- 20926694
OWN - NLM
STAT- MEDLINE
DCOM- 20110307
LR  - 20211020
IS  - 1556-679X (Electronic)
IS  - 1556-6811 (Print)
IS  - 1556-679X (Linking)
VI  - 17
IP  - 12
DP  - 2010 Dec
TI  - Porcine reproductive and respiratory syndrome virus infection at the time of 
      porcine circovirus type 2 vaccination has no impact on vaccine efficacy.
PG  - 1940-5
LID - 10.1128/CVI.00338-10 [doi]
AB  - Several porcine circovirus type 2 (PCV2) vaccines are now commercially available 
      and have been shown to be effective at decreasing the occurrence of porcine 
      circovirus-associated disease (PCVAD). Many herds are coinfected with PCV2 and 
      porcine reproductive and respiratory syndrome virus (PRRSV). Some producers and 
      veterinarians are concerned that if pigs are vaccinated for PCV2 at or near the 
      time that they are typically infected with PRRSV, the efficacy of the PCV2 
      vaccine will be compromised. The impact of PRRSV on PCV2 vaccination is unclear 
      and has not been investigated under controlled conditions. The objective of the 
      present study was to determine whether the presence of PRRSV viremia has an 
      effect on the efficacy of commercial PCV2 vaccinations. Three-week-old 
      PCV2-negative conventional pigs with passively derived anti-PCV2 antibodies were 
      either vaccinated with one of three commercial PCV2 vaccines or left 
      nonvaccinated. A portion of the pigs were infected with PRRSV 1 week prior to 
      PCV2 vaccination. To determine vaccine efficacy, a PCV2 challenge was conducted 
      at 8 weeks of age. PCV2 vaccination, regardless of PRRSV infection status at the 
      time of vaccination, was similarly effective in inducing an anti-PCV2 IgG 
      response in the presence of maternally derived immunity and in protecting the 
      pigs from PCV2 challenge, as determined by a reduction in the level of PCV2 
      viremia and a reduction in the prevalence and amount of PCV2 antigen in lymphoid 
      tissues in vaccinated pigs compared to nonvaccinated pigs. The results indicate 
      that acute PRRSV infection at the time of PCV2 vaccination has no adverse effect 
      on PCV2 vaccine efficacy.
FAU - Sinha, A
AU  - Sinha A
AD  - Department of Veterinary Diagnostic and Production Animal Medicine, College of 
      Veterinary Medicine, Iowa State University, Ames, IA 50011, USA.
FAU - Shen, H G
AU  - Shen HG
FAU - Schalk, S
AU  - Schalk S
FAU - Beach, N M
AU  - Beach NM
FAU - Huang, Y W
AU  - Huang YW
FAU - Halbur, P G
AU  - Halbur PG
FAU - Meng, X J
AU  - Meng XJ
FAU - Opriessnig, T
AU  - Opriessnig T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101006
PL  - United States
TA  - Clin Vaccine Immunol
JT  - Clinical and vaccine immunology : CVI
JID - 101252125
RN  - 0 (Antibodies, Viral)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - Antibodies, Viral/blood
MH  - Circoviridae Infections/prevention & control/*veterinary
MH  - Circovirus/*immunology
MH  - Immunoglobulin G/blood
MH  - Lymphoid Tissue/virology
MH  - Porcine Reproductive and Respiratory Syndrome/*immunology
MH  - Porcine respiratory and reproductive syndrome virus/*isolation & purification
MH  - Swine
MH  - Swine Diseases/immunology/*prevention & control
MH  - Time Factors
MH  - Vaccination/methods
MH  - Viral Vaccines/administration & dosage/*immunology
MH  - *Viremia
PMC - PMC3008187
EDAT- 2010/10/12 06:00
MHDA- 2011/03/08 06:00
PMCR- 2011/06/01
CRDT- 2010/10/08 06:00
PHST- 2010/10/08 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2011/03/08 06:00 [medline]
PHST- 2011/06/01 00:00 [pmc-release]
AID - CVI.00338-10 [pii]
AID - 0338-10 [pii]
AID - 10.1128/CVI.00338-10 [doi]
PST - ppublish
SO  - Clin Vaccine Immunol. 2010 Dec;17(12):1940-5. doi: 10.1128/CVI.00338-10. Epub 
      2010 Oct 6.